|Application:||Gene expression microarray analysis|
|Number of samples:||24|
|Release date:||Dec 31 2016|
|Last update date:||Jun 30 2017|
|Dataset link||Reduced mTORC1 activity is associated with responsiveness to MEK inhibition (PD0325901) in gastric cancer cells.|
To identify genes specifically induced in MEK inhibitor-sensitive cell lines after MEK inhibition, we treated MEK inhibitor (PD0325901)-sensitive (HSC57 and SNU719) and -resistant (SH-10-TC and TMK1) cell lines with 1µM PD0325901 for 3 h. Then, RNAs were extracted from these cells and susequently subjected to gene expression-microarray analysis. The expression levels were normalized by the median expression for the all 24 samples (each 4 cell lines n=3) and expressed as log2ratio.