Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 24
Release date: Dec 31 2016
Last update date: Jun 30 2017
Access: Public
Diseases: Stomach Neoplasms
Chemicals: Tyrosine
Dataset link Reduced mTORC1 activity is associated with responsiveness to MEK inhibition (PD0325901) in gastric cancer cells.

Experimental Protocol


To identify genes specifically induced in MEK inhibitor-sensitive cell lines after MEK inhibition, we treated MEK inhibitor (PD0325901)-sensitive (HSC57 and SNU719) and -resistant (SH-10-TC and TMK1) cell lines with 1µM PD0325901 for 3 h. Then, RNAs were extracted from these cells and susequently subjected to gene expression-microarray analysis. The expression levels were normalized by the median expression for the all 24 samples (each 4 cell lines n=3) and expressed as log2ratio.

Repositories


GEO

GSE74842

BioProject

PRJNA301631

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Contact


yuka hirashita