Computational protocol: Combined 3 Tesla MRI Biomarkers Improve the Differentiation between Benign vs Malignant Single Ring Enhancing Brain Masses

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Protocol publication

[…] Significant differences between malignant lesions and benign lesions as well as between metastases and GBMs were assessed by using Mann-Withney U test.Principal component analysis (PCA) and Partial Least Square Discriminant Analysis (PLS-DA) were performed in order to find MRI variables discriminating between malignant and benign lesions. Data were mean centered, scaled to unit variance, and log transformed before analysis.The diagnostic accuracy of MRI biomarkers taken alone or combined by calculating the ratios between pairs of MRI biomarkers, were also investigated by using the Receiver Operating Characteristic (ROC) curve analysis. ROC curve provides the sensitivity (true positive rate) and the specificity (false positive rate) of a diagnostic test, representing the ability of a variable to discriminate between two groups; an Area Under the Curve (AUC) ≥ 0.9 indicates a very good diagnostic accuracy.ROC curve analysis was performed by using the ROC curve analysis tool [ROC Curve Explorer and Tester (ROCCET) available at]. Softwares used for statistical analysis were SIMCA P+ version 11.0 (Umetrics, Umeá, Sweden), and Statistica 6.0 (Statsoft, Tulsa, OK). […]

Pipeline specifications

Software tools mixOmics, Statistica
Applications Miscellaneous, Magnetic resonance imaging
Organisms Homo sapiens
Diseases Glioblastoma
Chemicals Choline, Chromium, Creatine, Lactic Acid, Succinic Acid