Computational protocol: The relationships between brain structural changes and perceived loneliness in older adults suffering from late‐life depression

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Protocol publication

[…] The acquired structural brain images were preprocessed using the VBM8 toolbox ( implemented in SPM8 (Wellcome Trust Centre for Neuroimaging, London, UK). The East Asian template was used for affine registration. GM, WM, and cerebrospinal fluid were categorized from the images. High‐dimensional DARTEL was used for spatial normalization, as it was sensitive enough to examine small brain structures and was the optimal approach for whole‐brain alignment. Normalized, unsegmented images were visually inspected for gross artifacts resulting from normalization. Finally, both GM and WM segments were smoothed with an 8‐mm, full‐width half‐maximum Gaussian kernel by SPM8.Whole‐brain analyses were conducted on the smoothed T1 images using a general linear model that involved permutation test (5000 iterations) through the FMRIB Software Library (FSL)‐randomize approach. The interaction model was Group (categorical variable) × LS (continuous variable). A contrast between the 3 groups would be considered significant when a significant difference between GM volume and the LS scores was found. For each significant cluster, average GM volume was extracted and then correlated with LS scores for each of the 3 groups. P < .01 was set as the threshold for the analyses. […]

Pipeline specifications

Software tools SPM, FSL
Application Neuroimaging analysis