Computational protocol: Data on common variants associated with coronary artery disease/myocardial infarction in ethnic Arabs

Similar protocols

Protocol publication

[…] The discovery study involved 5668 Saudi Arabs who were subjected to genotyping using Affymetrix Axiom Genome-Wide ASI Array (Asian population). Genotyping data were generated using the Axiom GT1 algorithm and an IBS/IBD analysis in PLINK . Analyses of the genome-wide association (GWA) were based on a linear mixed model method using FASTLMM-Select with Principal Component (PCs) as in Lippert et al. and Widmer et al. . Heritability estimation was performed according to Yang et al. implemented in Genome-wide Complex Trait analysis (GCTA) software and extended in REACTA. The population substructure was examined by Principal Component Analysis (PCA) using the GCTA as described by Yang and colleagues to eliminate the outliers that do not conform to the main cluster of samples that form the Saudi cohort, and may therefore lead to false positive results. […]

Pipeline specifications

Software tools PLINK, GCTA
Application GWAS
Diseases Coronary Artery Disease, Myocardial Infarction