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FactorXI specifications


Unique identifier OMICS_28627
Name FactorXI
Alternative name Factor XI
Restrictions to use Academic or non-commercial use
Community driven No
Data access Browse
User data submission Not allowed
Version 2.2
Maintained Yes


  • person_outline Stephen Perkins

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Publication for FactorXI

FactorXI citations


Integrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal Matrix

PLoS Genet
PMCID: 4970718
PMID: 27482894
DOI: 10.1371/journal.pgen.1006205

[…] rms that each contain a signal peptide, two PAN-Apple domains, and a C-terminal ZP domain. PAN-Apple domains are putative protein or carbohydrate interaction domains found in plasminogen and clotting factor XI, as well as in various invertebrate cuticle proteins [,]. ZP domains are polymerization-competent domains found in many apical matrix proteins, including invertebrate cuticle proteins [,–]. […]


Identification and Molecular Characterization of Microneme 5 of Eimeria acervulina

PLoS One
PMCID: 4274027
PMID: 25531898
DOI: 10.1371/journal.pone.0115411

[…] ndii. Compared to the EtMIC5 sequences published , we found that there were no transmembrane region and signal region for GPI anchor attachment in EaMIC5 sequences. BLASTP analysis revealed two Apple Factor XI like regions in the EaMIC5, which were similar to the eleven cysteine-rich receptor-like regions with striking similarity to the Apple domains (A-domains) of the binding regions of blood coa […]


Lack of Plasma Kallikrein Kinin System Cascade in Teleosts

PLoS One
PMCID: 3835742
PMID: 24278376
DOI: 10.1371/journal.pone.0081057

[…] ed from uncharacterized or novel proteins. Three dimensional structures of human KLKB1, coelacanths KLKB1, and medaka skin mucus lectin were modeled against the crystal structure of human coagulation factor XI zymogen (2f83A) using a protein structure prediction server []. […]


Multivariate Analysis of Dopaminergic Gene Variants as Risk Factors of Heroin Dependence

PLoS One
PMCID: 3696122
PMID: 23840506
DOI: 10.1371/journal.pone.0066592
call_split See protocol

[…] rget from the effect of the other variables . This set of variables X’ (a subset of all variables X) is called a Markov blanket set (MBS(Y)) of variables with regard to target Y. For a given variable/factor Xi, being a member of MBS is called Markov blanket membership (MBM(Y, Xi)). The Bayesian framework allows us to calculate the posterior probabilities of these properties by performing a random […]


RNA Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats

PLoS One
PMCID: 3632591
PMID: 23630614
DOI: 10.1371/journal.pone.0061768

[…] ASeq data await further experimental validation.A few examples of Novel-T, Novel-U and Overlap exons are presented in and . RefSeq and Ensembl annotations are shown in for the F11 gene (coagulation factor XI) for which a Novel-T exon was found by Cufflinks in both treatment groups. It seems reasonable that this transcript could include an alternative start site for F11 since this Novel-T exon ap […]


Ss Sl2, a Novel Cell Wall Protein with PAN Modules, Is Essential for Sclerotial Development and Cellular Integrity of Sclerotinia sclerotiorum

PLoS One
PMCID: 3338822
PMID: 22558105
DOI: 10.1371/journal.pone.0034962

[…] 1, the top-ranked hits is PAN module in hepatocyte growth factor (HGF), with an E-value of 0.76 (P-value of 3E-05) and a probability score of 79.2. The second-ranked hits is PAN module in coagulation factor XI (FXI), with an E-value of 2.4 (P-value of 9.4E-05) and a probability score of 73.3. For Ss-Sl2D2, the top-ranked hits is PAN module in coagulation factor XI (FXI), with a modest E-value of 3 […]

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FactorXI institution(s)
Institute of Structural and Molecular Biology, University College London, London, UK; Haemophilia Centre and Thrombosis Unit, Royal Free Hospital, London, UK; Department of Haematology, Addenbrookes Hospital, Cambridge, UK
FactorXI funding source(s)
Supported by grants from the Medical Research Council and the Wellcome Trust.

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