|Number of samples:||27|
|Release date:||Nov 8 2016|
|Last update date:||Nov 30 2018|
|Dataset link||Genome-wide analysis of transcription in in vitro- and in vivo-derived motor neurons|
The goal of this study is to determine the level of transcriptional similarity between spinal motor neurons generated from pluripotent stem cells by directed differentation, spinal motor neurons generated from fibroblasts by transcription factor-mediated lineage conversion, and primary spinal motor neuron from embryonic spinal cord. In addition, we tested the effect of culturing ESC-MNs in glia-conditioned media. All neurons were generated using the same Hb9::GFP, C57Bl/6 background, and FACS sorted for Hb9::GFP.