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FAM-MDR specifications


Unique identifier OMICS_10123
Alternative name FAMily Multifactor Dimensionality Reduction
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
Computer skills Advanced
Stability Stable
Maintained Yes


No version available


  • person_outline Tom Cattaert

Publication for FAMily Multifactor Dimensionality Reduction

FAM-MDR citations


Fuzzy set based generalized multifactor dimensionality reduction analysis of gene gene interactions

BMC Med Genomics
PMCID: 5918459
PMID: 29697366
DOI: 10.1186/s12920-018-0343-0

[…] luding quantitative MDR, for quantitative traits []; generalized MDR (GMDR), for both quantitative and binary traits []; MB-MDR, based on statistical testing [], Surv/Cox-MDR, for survival data [, ]; FAM-MDR, for family data [], GEE/Multi-MDR, for multivariate traits [, ], etc.Among the many extensions of MDR, GMDR tests GGIs using residuals of a generalized linear model as score statistics. This […]


A Review for Detecting Gene Gene Interactions Using Machine Learning Methods in Genetic Epidemiology

Biomed Res Int
PMCID: 3818807
PMID: 24228248
DOI: 10.1155/2013/432375

[…] tions in the presence (or absence) of main effects of genes with an adjustment of covariates. The result showed that proposed extended SVM and SVM-based PGMDR have high accuracy compared to PGMDR and FAM-MDR (family-based multifactor dimensionality reduction). Moreover, the extended SVM method has the highest prediction accuracy, but it possesses low consistencies if compared to SVM-based PGMDR me […]


Gene Gene Interaction and Functional Impact of Polymorphisms on Innate Immune Genes in Controlling Plasmodium falciparum Blood Infection Level

PLoS One
PMCID: 3470565
PMID: 23071570
DOI: 10.1371/journal.pone.0046441

[…] uced by Ritchie, et al. is a computational strategy to detect and characterize gene-gene interactions that may be associated with disease susceptibility . So far, MDR and its extensions such as GMDR, FAM-MDR, MDR-PDT, EMDR – have identified many interacting genetic variants underlying a wide variety of complex human diseases such as Alzheimer's disease, asthma, atrial fibrillation, autism, bladder […]


Multilocus Family Based Association Analysis of Seven Candidate Polymorphisms with Essential Hypertension in an African Derived Semi Isolated Brazilian Population

PMCID: 3463917
PMID: 23056922
DOI: 10.1155/2012/859219
call_split See protocol

[…] ted in sensitivity analyses.Under a family-based design, we investigate all possible two-way multilocus effects using the recently proposed flexible family-based multifactor dimensionality reduction (FAM-MDR) approach []. The current framework of the FAM-MDR procedure focuses on potential multilocus associations for quantitative traits and can be schematically separated in two main stages. In the […]


Comparison of genetic association strategies in the presence of rare alleles

BMC Proc
PMCID: 3287868
PMID: 22373505
DOI: 10.1186/1753-6561-5-S9-S32

[…] should be noted that genetic information is the same for all replicates; only phenotype and smoking status differ.For the family data, we compare the performance of the MB-MDR approach (family-based, FAM-MDR) to the association test (PBAT) screening [-] (version 3.61), whereas for unrelated individuals we compare the MB-MDR approach to penalized regression (the penalized package in R, v. 2.9). Pow […]


Comparison of information theoretic to statistical methods for gene gene interactions in the presence of genetic heterogeneity

BMC Genomics
PMCID: 2996983
PMID: 20815886
DOI: 10.1186/1471-2164-11-487

[…] mproved and used to analyze quantitative phenotypes and family data [-], computational efficiency remains the rate-limiting factor irrespective the improvements [,]. Cattaert et al. [] have developed FAM-MDR method, which addresses correlation between observations in family-based studies and extends the model based MB-MDR approach [] to handle continuous covariates and continuous phenotype. In con […]


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FAM-MDR institution(s)
Montefiore Institute, University of Liège, Liège, Belgium; Groupe Interdisciplinaire de Génoprotéomique Appliquée - Research, University of Liège, Liège, Belgium

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