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FBAT specifications


Unique identifier OMICS_07500
Alternative name Family Based Association Test
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Computer skills Advanced
Stability No
Maintained No


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Publications for Family Based Association Test

FBAT citations


WISARD: workbench for integrated superfast association studies for related datasets

BMC Med Genomics
PMCID: 5918457
PMID: 29697360
DOI: 10.1186/s12920-018-0345-y

[…] maximum likelihood for estimation and approximations to avoid numerical integration have a serious bias introduced by the approximation [, ]. In order to overcome this issue, score statistics such as FBAT [] and MQLS [] have been proposed as alternatives.However, in spite of such improvement, there is no integrated toolset for an analysis of large-scale family-based samples, and statistical analys […]


Genetic variants of SLC12A3 modulate serum lipid profiles in a group of Mongolian pedigree population

PMCID: 5902855
PMID: 29661184
DOI: 10.1186/s12944-018-0737-1
call_split See protocol

[…] c variables was evaluated by multiple regression analysis, within parental group. To identify potential Mendelian errors, the PEDCHECK program was used to test the family structure before running the family-based association test []. The pedigrees, which were not consistent with Mendelian inheritance, were excluded from quantitative phenotypic analysis. For single marker, it was analyzed by FBAT p […]


Genome wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French Canadian population

Sci Rep
PMCID: 5847615
PMID: 29531279
DOI: 10.1038/s41598-018-21603-7

[…] vealed that only CCDC80 (p = 0.01) in 3q13.2 reached the statistical significance after accounting for multiple testing.In the Nunavik Inuit IA cohort, after performing Family Based Association Test (FBAT) of the 2,429 SNPs within the 28 aforementioned genes and neighboring regions, 50 SNPs located in the FHIT gene region were with p < 0.05 (Supplementary Table ), the most significant one being rs […]


Advances in the Genetics of Hypertension: The Effect of Rare Variants

Int J Mol Sci
PMCID: 5877549
PMID: 29495593
DOI: 10.3390/ijms19030688

[…] model, may be able to use both family and unrelated samples (developed for quantitative traits). Wang and coauthors in 2016 [] proposed four weighting schemes for the family-based rare variants test (FBAT-v) []. Lee and coauthors in 2012 [] derived the optimal test SKAT-O by estimating the correlation parameter in the kernel matrix to maximize the power, which corresponds to the estimated weight i […]


Maternal transmission disequilibrium of rs2248359 in type 2 diabetes mellitus families and its association with vitamin D level in offspring

Sci Rep
PMCID: 5778029
PMID: 29358755
DOI: 10.1038/s41598-018-19838-5

[…] We analyzed the data by following strategies. First, the family-based association test (FBAT) software (V2.0.4Q, https://www.hsph.harvard.edu/fbat/fbat.htm) was applied to examine the association between rs2248359 and T2DM. Second, distributions of rs224835 […]


CRP level associated polymorphism rs1205 within the CRP gene is associated with 2 hour glucose level: The SAPPHIRe study

Sci Rep
PMCID: 5554245
PMID: 28801571
DOI: 10.1038/s41598-017-08696-2
call_split See protocol

[…] l with multiple testing.To demonstrate that significant SNP-trait associations observed in GEE analysis were not caused by population stratification, the observed associations were re-examined by the FBAT analysis, which has the advantage of avoiding confounding due to population stratification. The software FBAT 2.0.4 was used to implement the FBAT analysis and one-sided p-value was calculated. […]


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FBAT institution(s)
Department of Biostatistics, Harvard University, Boston, MA, USA; Department of Biostatistics, Columbia University, New York, NY, USA
FBAT funding source(s)
Supported by FBAT (Family Based Association Tests) grant.

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