Computational protocol: Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder

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Protocol publication

[…] Statistical analysis was performed using IBM SPSS Statistics for Windows, version 20.0. Data are expressed as mean ± SEM. Differences between the genotype and diet were determined by analysis of variance (ANOVA), followed by Tukey’s post hoc test where p < 0.05 was considered to be significant. Microbial data was normalized and uploaded into MetaboAnalyst 3.0 for modeling using partial least squares discriminant analysis (PLS-DA). Variable importance of projection (VIP) scores were assessed in order to rank each microbial group for their degree of discrimination within the model. […]

Pipeline specifications

Software tools SPSS, MetaboAnalyst
Application Miscellaneous
Organisms Mus musculus, Akkermansia muciniphila
Diseases Gastrointestinal Diseases