A comprehensive drug target database for lymphatic filariasis (Lf), one of the oldest and most debilitating tropical diseases. FiloBase models and stores therapeutic targets for Lf. In addition, forty drug targets of Brugia malayi were modelled and incorporated in FiloBase. In order to supplement and make it more informative, other significant filarial information such as expressed sequence tags, potential epitopes, experimental drugs, experimental structures of nematode proteins were incorporated in FiloBase by extensive literature survey which was in demand to facilitate the drug discovery process of Lf. At present, FiloBase contains 119 potential drug targets for Lf; we hope that FiloBase will be worthwhile to expedite the process of drug discovery for the better treatment of Lf.