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FILTUS specifications


Unique identifier OMICS_11098
Software type Application/Script
Interface Graphical user interface
Restrictions to use None
Input data FILTUS accepts virtually any variant files, in contrast to most existing programs which are limited to VCF or other specific input formats.
Operating system Unix/Linux, Mac OS, Windows
Programming languages Python
License GNU General Public License version 2.0
Computer skills Medium
Version 1.0.3
Stability Stable
Maintained Yes




No version available


  • person_outline Magnus Vigeland

Publication for FILTUS

FILTUS citations


PUF60 variants cause a syndrome of ID, short stature, microcephaly, coloboma, craniofacial, cardiac, renal and spinal features

Eur J Hum Genet
PMCID: 5392357
PMID: 28327570
DOI: 10.1038/ejhg.2017.27
call_split See protocol

[…] ilent Technologies, Santa Clara, CA, USA) identified exonic and periexonic fragments, followed by massive parallel next-generation sequencing. Analysis of exome data was undertaken with DeNovoGear or FILTUS, and for patient 11, raw data was processed using an end-to-end in-house database. Identified variants were annotated using standard databases and were filtered based on the established criteri […]


Novel PIGT Variant in Two Brothers: Expansion of the Multiple Congenital Anomalies Hypotonia Seizures Syndrome 3 Phenotype

PMCID: 5192484
PMID: 27916860
DOI: 10.3390/genes7120108
call_split See protocol

[…] K) [] was used to analyze the WES data and functional annotation was performed with snpEff [] and Variant Effect Predictor (VEP), using Ensembl release 71 []. WES data was filtered and analyzed using FILTUS v.0.99-934 []. Variants were removed if they had a high probability of being technical artifacts, as computed by the GATKs “variant quality score recalibration” procedure, occurred with a frequ […]


A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T‐cell dysfunction

PMCID: 5118205
PMID: 27896283
DOI: 10.1002/mgg3.237

[…] For the Oslo samples, FILTUS (Vigeland et al. ) was used for variant filtering and prioritization. Rare, high‐quality variants were selected based on NHLBI Exome Sequencing Project (ESP), 1000 Genomes (1000 Genomes Project […]


Segregation of Incomplete Achromatopsia and Alopecia Due to PDE6H and LPAR6 Variants in a Consanguineous Family from Pakistan

PMCID: 4999829
PMID: 27472364
DOI: 10.3390/genes7080041
call_split See protocol

[…] using annotations GRCh 37.64 and Ensembl 71, respectively. The Integrative Genomic Viewer [] was used for data visualization.The annotated variant files were filtered and analyzed using the software FILTUS 0.99-91 []. Variants in genes known to generate false positive signals in exome sequencing were discarded [], together with variants with minor allele frequency higher than 0.01 according to th […]


A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine

PMCID: 4559173
PMID: 25860647
DOI: 10.1007/s10689-015-9803-2
call_split See protocol

[…] tFiltration with parameter settings according to recommendations in SEQanswers exome sequencing analysis guide []. Variants were annotated with ANNOVAR []. Filtering was done using the filtering tool FILTUS version 0.99-9 []. We used two filtering strategies to find causative variant(s). The first approach was based on disease status which would enable us to find variants in potentially novel canc […]


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FILTUS institution(s)
Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway; Cancer Registry of Norway, Department of Research, Oslo, Norway
FILTUS funding source(s)
This work has been supported by the South-Eastern Norway Regional Health Authority [2012066].

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