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FireProt specifications


Unique identifier OMICS_17898
Name FireProt
Interface Web user interface
Restrictions to use None
Computer skills Basic
Version 1.1
Stability Stable
Maintained Yes


  • person_outline David Bednar

Publication for FireProt

FireProt citation


FireProt: Energy and Evolution Based Computational Design of Thermostable Multiple Point Mutants

PLoS Comput Biol
PMCID: 4631455
PMID: 26529612
DOI: 10.1371/journal.pcbi.1004556

[…] individual mutations []. For all those reasons, no computational method capable of directly designing highly stable multiple-point mutants has been previously published.Here we introduce a strategy, FireProt, for computationally designing multiple-point mutants, enabling significant improvements of protein stability with minimal experimental effort. We demonstrate its power by stabilizing the mod […]

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FireProt institution(s)
Loschmidt Laboratories, Department of Experimental Biology, Masaryk University, Brno, Czech Republic; Department of Information Systems, Faculty of Information Technology, Brno University of Technology, Brno, Czech Republic; International Centre for Clinical Research, St. Anne’s University Hospital Brno, Brno, Czech Republic; Centre of Excellence IT4Innovations, Technical University Ostrava, Ostrava
FireProt funding source(s)
This work was supported by Ministry of Education, Youth and Sports of the Czech Republic from the National Programme of Sustainability II [LQ1605, LO1214], European Regional Development Fund [ELIXIR-CZ LM2015047], Grant Academy of the Czech Republic [16-06096S] and by Brno University Technology [FIT-S- 17-3964].

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