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Fleximer specifications


Unique identifier OMICS_25170
Name Fleximer
Software type Application/Script
Interface Command line interface
Restrictions to use None
Input data A predefined partition of transcriptome or a RNA-Seq data.
Input format FASTA
Output data A desired read length or a read count.
Operating system Unix/Linux
Programming languages C++
Computer skills Advanced
Stability Stable
Maintained Yes




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  • person_outline Chelsea Ju <>

Publication for Fleximer

Fleximer citations


Nucleoside analogs as a rich source of antiviral agents active against arthropod borne flaviviruses

PMCID: 5890575
PMID: 29534608
DOI: 10.1177/2040206618761299

[…] that has been shown to impart significant activity to the nucleoside scaffold as well as to allow it to overcome resistance related to point mutations.– the most recent series combined the fleximer approach with the acyclic nucleoside acyclovir, an fda approved drug for herpes virus. while these analogs inhibited the aforementioned viruses, acyclovir shows no activity […]


Flexibility—Not just for yoga anymore!

PMCID: 5890542
PMID: 29466861
DOI: 10.1177/2040206618756788

[…] binding site, particularly when faced with an electronic or steric interference. since point mutations typically involve these sorts of amino acid changes, we also hypothesized this would allow the fleximer to adjust and engage a secondary amino acid residue not previously involved in the mechanism of action. this would in turn allow it to retain its activity, something a rigid analogue would […]


Antibody engineering and therapeutics, the annual meeting of the antibody society December 7–10, 2015, San Diego, CA, USA

PMCID: 4966842
PMID: 26909869
DOI: 10.1080/19420862.2016.1153211

[…] special adc track, which focused on improving adc properties, widening therapeutic windows or maximizing potencies., timothy lowinger (mersana) discussed advancing the dolaflexin platform and other fleximer-based adcs toward the clinic. the dolaflexin platform is the most advanced at mersana establishing a dar of ∼15 of a proprietary auristatin payload and using a fully biodegradable fleximer […]


Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents

PMCID: 5588531
PMID: 26679767
DOI: 10.1159/000443404

[…] prodrug of cpt (molecular weight: 70 kda), in which cpt is conjugated to a hydrophilic, biodegradable polyacetal polymer, poly(1-hydroxymethylethylene hydroxymethylformal), also known as phf or fleximer®, and is slowly released []. the recent advances with sn-38 (7-ethyl-10-hydroxy cpt: 12; fig. ) have been summarized in a recent review []. among the promising products developed […]


World Antibody Drug Conjugate Summit, October 15–16, 2013, San Francisco, CA

PMCID: 3929441
PMID: 24423618
DOI: 10.4161/mabs.27437

[…] the session with a discussion of a contract manufacturing approach to bring an adc from the lab to the clinic and ultimately to the market., tim lowinger (mersana therapeutics) presented the fleximer platforms, which consist of a clinically-validated biodegradable polymer, with a broad array of customizable linker chemistries (conjugation to lysine or cysteine) matched to therapeutic […]


ATP Driven Remodeling of the Linker Domain in the Dynein Motor

PMCID: 3469822
PMID: 22863569
DOI: 10.1016/j.str.2012.07.003

[…] image processing. this is significant because cryo-em provides an ideal complement to x-ray crystallography, the latter providing high-resolution structural information but typically of only one “fleximer” () that makes good crystal contacts. because our results indicate that dynein's flexibility and dynamics have a critical bearing on the motile mechanism, cryo-em is likely to play […]

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Fleximer institution(s)
Department of Computer Science, University of California, Los Angeles, CA, USA

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