Allows a large-scale analysis on a large collection of annotated influenza sequences. FluKB is a knowledge-based system that integrates multiple types of influenza data and analytical tools into workflows to support vaccine target discovery. The database contains standardized data, integrating information on antigen sequences, and immunological epitopes. The set of integrated analysis tools and workflows are designed to aid rational vaccine design that integrates the content and the analytical tools in a unified system that enables the automation of complex queries and discovery.
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark; Department of Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark; Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark; Department of Computer Science, Metropolitan College, Boston University, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Laboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA