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Foldit specifications


Unique identifier OMICS_18147
Name Foldit
Alternative name Foldit Standalone
Software type Application/Script
Interface Graphical user interface
Input format PDB, FASTA
Operating system Unix/Linux, Mac OS, Windows
Programming languages C++
Computer skills Medium
Stability Alpha
Maintained Yes


No version available


  • person_outline Seth Cooper

Additional information

Publications for Foldit

Foldit citations


Interaction of the GntR family transcription factor Sll1961 with thioredoxin in the cyanobacterium Synechocystis sp. PCC 6803

Sci Rep
PMCID: 5923263
PMID: 29703909
DOI: 10.1038/s41598-018-25077-5
call_split See protocol

[…] in detail in Supplementary Text and Supplementary Table . Three-dimensional structure predictions were performed using the I-TASSER server. Docking predictions were performed using the ZDOCK server. Foldit Standalone was used for manual refinement of predicted structures. […]


A Review on the Applications of Crowdsourcing in Human Pathology

J Pathol Inform
PMCID: 5841017
PMID: 29531847
DOI: 10.4103/jpi.jpi_65_17

[…] tration (e.g., ReCAPTCHA[]), and learning in education (i.e., incorporating crowdsourcing in the curriculum of courses[]). Regarding megatasks, authors mentioned two possible forms: hard games (e.g., Foldit[] and EteRNA[]), and open innovation contests (e.g., DREAM challenges[]). They distinguish casual games and hard games according to the incentive for the gamers, which is engagement in repetiti […]


Assemble And Match: A Novel Hybrid Tool for Enhancing Education and Research in Rational Structure Based Drug Design

Sci Rep
PMCID: 5770410
PMID: 29339792
DOI: 10.1038/s41598-017-18151-x

[…] might be manifested more strikingly in the current version, the prospective tool is expected to provide more efficient screening processes by exploiting the cognitive abilities of humans. Inspired by Foldit, a crowd-sourcing computer game which enables its players to contribute to solving the protein folding problem, we envision that Assemble-And-Match can become a crowd-sourcing physical game for […]


Can human experts predict solubility better than computers?

J Cheminform
PMCID: 5729181
PMID: 29238891
DOI: 10.1186/s13321-017-0250-y

[…] uld increase or decrease solubility. It might seem surprising that a computer could not, with the advantages described above, outperform a human at such a task. Nonetheless, human participants in the FoldIt project have been able to make useful contributions even in a field as apparently computation-intensive as protein folding, at least once the problem was suitably gamified []. Perhaps, some of […]


A cyber linked undergraduate research experience in computational biomolecular structure prediction and design

PLoS Comput Biol
PMCID: 5720517
PMID: 29216185
DOI: 10.1371/journal.pcbi.1005837

[…] immune stimulation []; this work continues in the host lab and has enabled new collaborations with experimental labs. Another intern examined the computer–human interface for the protein-folding game FoldIt [] to measure how three-star rating systems affect game player persistence []. One student designed co-assembling multicomponent protein crystals, and the host lab invited him back for a second […]


Integrative biological simulation praxis: Considerations from physics, philosophy, and data/model curation practices

PMCID: 5739097
PMID: 29296511
DOI: 10.1080/21592799.2017.1392400

[…] a brief training period in which they are familiarized with the existing taxonomy, GalaxyZoo was able to classify over 50 million images in the first year, taking advantage of over 150,000 volunteers.FoldIt is an example of a biological open science project that has generated a tremendous amount of data by taking advantage of large numbers of human volunteers. Employing a strategy known as “gamifi […]


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Foldit institution(s)
College of Computer and Information Science, Northeastern University, Boston, MA, USA; Department of Computer Science and Engineering, University of Washington, Seattle, WA, USA; Department of Biochemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Biochemistry, University of Washington, Seattle, WA, USA; Institute for Protein Design, University of Washington, Seattle, WA, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA; Genome Center, University of California Davis, Davis, CA, USA; Department of Chemistry, University of California Davis, Davis, CA, USA; Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, CA, USA; Department of Computer and Information Science, University of Massachusetts Dartmouth, Dartmouth, MA, USA
Foldit funding source(s)
Supported by the National Science Foundation [1629879]; the National Institutes of Health [1UH2CA203780]; and RosettaCommons.

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