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In population genetics, simulation is a fundamental tool for analyzing how basic evolutionary forces such as natural selection, recombination, and mutation shape the genetic landscape of a population. Forward simulation represents the most powerful, but, at the same time, most compute-intensive approach for simulating the genetic material of a population.
(Aberer and Stamatakis, 2013) Rapid forward-in-time simulation at the chromosome and genome level. BMC Bioinformatics.