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FREP specifications


Unique identifier OMICS_07826
Restrictions to use None
Maintained No


  • Rodents
    • Mus musculus


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Publication for FREP

FREP citations


CRISPR/Cas9 mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection

PLoS Pathog
PMCID: 5843335
PMID: 29518156
DOI: 10.1371/journal.ppat.1006898

[…] For the design of guide RNA (gRNA) targets, manually searching the FREP1 coding sequence for the PAMs (NGG) was initially undertaken, with N representing any nucleotide. We checked candidate gRNA sequences for potential off-target binding using the following web tool […]


Characterization of Ixodes ricinus Fibrinogen Related Proteins (Ixoderins) Discloses Their Function in the Tick Innate Immunity

PMCID: 5727070
PMID: 29276701
DOI: 10.3389/fcimb.2017.00509
call_split See protocol

[…] The search for tick fibrinogen-related proteins (FReP) was performed using the I. scapularis genome database ( or GenBank ( The primary amino acid sequence used for phylogenetic analysis comprised a co […]


The short term effect of high versus moderate protein intake on recovery after strength training in resistance trained individuals

PMCID: 5697135
PMID: 29200983
DOI: 10.1186/s12970-017-0201-z

[…] This study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the Faculty of Science and Technology Ethics Committee, Anglia Ruskin University (FST/FREP/15/556). Informed consent was obtained from all individual participants included in the study. Sample size was based on an a priori power analysis using G*Power (v., Dusseldorf []) to dete […]


Proteomic analysis of Biomphalaria glabrata plasma proteins with binding affinity to those expressed by early developing larval Schistosoma mansoni

PLoS Pathog
PMCID: 5433772
PMID: 28520808
DOI: 10.1371/journal.ppat.1006081

[…] []. Genes encoding these FREPs also have been reported from other gastropod species including Aplysia californica [] and Littorina littorea [].One unexpected result that arose in our analysis of VIgL-FREP family proteins was the finding of proteins encoded in the B. glabrata genome that possessed a C-terminal fibrinogen domain (FReD), but lacked an N-terminal Ig-fold. The FReD-containing angiopoei […]


A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni

PLoS Negl Trop Dis
PMCID: 5349689
PMID: 28253264
DOI: 10.1371/journal.pntd.0005398

[…] Transcripts corresponding to potential FREP sequences were selected from transcriptomes on the basis of Blast2Go annotations or the presence of immunoglobulin and/or fibrinogen domains (IPR013783 and IPR002181, respectively), as detected b […]


Measurement of absolute frequency of continuous wave terahertz radiation in real time using a free running, dual wavelength mode locked, erbium doped fibre laser

Sci Rep
PMCID: 5301209
PMID: 28186148
DOI: 10.1038/srep42082

[…] shows a schematic diagram of the setup for measuring the frequency of CW-THz radiation The amplified λ1 pulse light at frep1 from one EDFA (EDFA1) was collimated in free space and then focused onto a gap in a free-space-coupled, bowtie-shaped, low-temperature-grown (LT) InGaAs/InAlAs PCA (PCA1, TERA15-BT3, Menlo Syste […]


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FREP institution(s)
Biomedical Knowledge Discovery Team, Bioinformatics Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan

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