fRMA specifications


Unique identifier OMICS_01994
Name fRMA
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License GNU General Public License version 2.0
Computer skills Advanced
Stability Stable
Maintained Yes


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  • person_outline Matthew McCall <>

fRMA article

fRMA citations

PMCID: 5493619

[…] lc treatment., the limma package was used to identify gene expression variations60 in control brain and lung samples, merging all the samples from the hg u133 plus 2 microarray platform and using frma61 for data normalization. we applied a principal component analysis to normalized expression data to evaluate the variability explained by the tissue’s origin. gene set enrichment analysis […]

PMCID: 4636487

[…] network analysis and training a consensus subtype classifier, all private and public affymetrix data sets were renormalized using the single-sample frozen rma method33 as implemented in the frma package for r/bioconductor., several of the crc tumor sets were analysed on full genome agilent microarrays (agilent, santa clara). samples were hybridized against a common crc reference pool, […]

PMCID: 4419490

[…] to approach 2: affymetrix cel files for patient-derived cell lines were imported into bioconductor/r for processing via 3 normalization procedures (rma, frma, and mas5.0 background correction; affy package) and differential expression analysis via paired t-test (limma package). significantly altered genes were identified as those with p < 0.05 […]

fRMA institution(s)
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, CU, Chinahester, NY, USA

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