G-quadruplex databases | RNA structure data analysis
RNA G-quadruplexes (G4s) are formed by G-rich RNA sequences in protein-coding (mRNA) and non-coding (ncRNA) transcripts that fold into a four-stranded conformation. Experimental studies and bioinformatic predictions support the view that these structures are involved in different cellular functions associated to both DNA processes (telomere elongation, recombination and transcription) and RNA post-transcriptional mechanisms (including pre-mRNA processing, mRNA turnover, targeting and translation).
A database containing information on the composition and distribution of putative Quadruplex-forming G-Rich Sequences mapped in average 29 000 eukaryotic pre-mRNA sequences, many of which are alternatively processed. GRSDB allows complex queries with a wide variety of parameters, including Gene Ontology terms. The database is useful for studying G-quadruplexes near RNA-processing sites particularly those that are differentially processed.
A reference database housing human RNA sequences already tested for G4 folding, along with their associated experimental data, provenance and relevant predictive measures. G4RNA was designed to help meet the need for easily-retrievable data on known RNA G4s. A user-friendly, flexible query system allows for data retrieval on experimentally tested sequences, from many separate genes, to assess G4-folding potential.
Provides a data resource for G-quadruplexes in human viruses. G4-virus includes a compressed tarball for each viral class of the Baltimore classification. This tarball contains multiple alignments in FASTA format, lists of g-quadruplex and their conversation in multiple alignments or to a reference sequence selected for each virus and some histograms of overlaps between G-quadruplexes and genomic features for each viral class.