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Tool usage distribution map

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Associated diseases

Associated diseases

G2D specifications

Information


Unique identifier OMICS_22630
Name G2D
Alternative name Genes to Diseases
Interface Web user interface
Restrictions to use None
Computer skills Basic
Version 5.0
Stability Stable
Maintained No

Maintainers


This tool is not available anymore.

Additional information


http://g2d2.ogic.ca/info/history.html#v5.0

Publication for Genes to Diseases

G2D in publications

 (6)
PMCID: 4217187
PMID: 25374782
DOI: 10.7717/peerj.639

[…] indirect relations from co-occurrence analysis () or based on interaction networks (; ). some combine different sources of information including the literature, such as endeavour (), disgenet (), g2d (), mimminer (), polysearch () or the approach proposed by . many of these methods could be effectively integrated into our approach., an alternative to utilising mesh annotations to establish […]

PMCID: 3117361
PMID: 21596790
DOI: 10.1093/bioinformatics/btr295

[…] or proteins and their orthologs in mouse models (). endeavour is trained on genes involved in a known biological process and ranks candidate genes after considering several genomic data sources (). g2d prioritization strategy is based on a combination of data mining on biomedical databases and sequence features (). polysearch analyzes biomedical databases to build relationships […]

PMCID: 2824729
PMID: 20122255
DOI: 10.1186/1471-2164-11-84

[…] operating characteristic (roc) analysis of the two methods, wv and hrc confirms their better performance (fig. ), with only prospectr [] having a higher sensitivity (0.90) than wv and hrc. where, g2d method gave accuracy and sensitivity of 0.73 and 0.53 respectively with the benchmarking dataset., numbers in bold letters indicate significant values, further, other gene prioritization methods […]

PMCID: 2488373
PMID: 18682798
DOI: 10.1371/journal.pone.0002907

[…] identify its environmental and genetic predisposing factors. here, we describe a novel methodological approach to select candidate genes for asthma genetic association studies. in this regard, the genes to diseases (g2d) computational tool has been used in combination with a genome-wide scan performed in a sub-sample of the saguenay−lac-st-jean (slsj) asthmatic familial collection (n = 609) […]

PMCID: 1933178
PMID: 17478516
DOI: 10.1093/nar/gkm223

[…] to the corresponding method. this means that some of them will correspond to well-known characterized genes, and others will overlap with predicted genes, thus providing a wider analysis. g2d is publicly available at http://www.ogic.ca/projects/g2d_2/, in the effort to identify which gene or genes produce what disease phenotype, geneticists are producing an increasing number […]


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G2D institution(s)
Ontario Genomics Innovation Centre, Ottawa Health Research Institute, Ottawa, ON, Canada; Institut für Epidemiologie, GSF Forschungszentrum für Umwelt undGesundheit Ingolstadter, Neuherberg/Munich, Germany; European Molecular Biology Laboratory, Heidelberg, Germany; Department of Bioinformatics, Max Delbrück Center for Molecular Medicine, Berlin, Germany

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