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GapAdj | A flexible ancestral genome reconstruction method based on gapped adjacencies


A synteny-based method that is flexible enough to handle a model of evolution involving whole genome duplication events, in addition to rearrangements, gene insertions, and losses. Ancestral relationships between markers are defined in term of Gapped Adjacencies, i.e. pairs of markers separated by up to a given number of markers. It improves on a previous restricted to direct adjacencies, which revealed a high accuracy for adjacency prediction, but with the drawback of being overly conservative, i.e. of generating a large number of contiguous ancestral regions (CARs).

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hello everyone, I am new in the community and I want to make an analysis that compares three PROCARS, GapAdj and Intercars, so I ask your help if you please

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GapAdj classification

GapAdj specifications

Unique identifier:
Software type:
Restrictions to use:
Output data:
An ancestral genome at node ν
Computer skills:
Gapped Adjacencies
Command line interface
Input data:
A set of modern genomes, a species tree S with leaves labeled with genomes, and an internal node of representing a speciation event of interest
Operating system:

GapAdj distribution


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GapAdj support


  • Dia El-Mabrouk <>


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Département d’Informatique (DIRO), Université de Montréal, Montréal, Canada; McGill Centre for Bioinformatics, McGill University, Montréal, Canada

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