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GastroPlus specifications

Information


Unique identifier OMICS_16038
Name GastroPlus
Software type Package/Module
Interface Graphical user interface
Restrictions to use License purchase required
Operating system Unix/Linux
Computer skills Medium
Version 9.5
Stability Stable
Maintained Yes

Versioning


No version available

Maintainer


  • person_outline DDDPlus Team

Additional information


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GastroPlus citations

 (51)
library_books

Pharmacokinetics and interspecies scaling of a novel, orally bioavailable anti cancer drug, SHetA2

2018
PLoS One
PMCID: 5892888
PMID: 29634717
DOI: 10.1371/journal.pone.0194046

[…] and later GI segments. To confirm this phenomenon, we analyzed the regional absorption of SHetA2 through different segments of the GI tract using the compartmental absorption and transit model in the GastroPlus for all doses administered in the dog. SHetA2 absorption in different GI regions was estimated by the calculated fraction absorbed. Simulations from the GastroPlus supported our modeling of […]

library_books

Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth

2018
PMCID: 5874844
PMID: 29518030
DOI: 10.3390/pharmaceutics10010031

[…] All PBPK models and simulations were performed using GastroPlus, version 9.0 (Simulations Plus Inc., Lancaster, CA, USA). This module simulates and predicts PK profiles of compounds using input parameters based on the physicochemical properties (e.g., s […]

library_books

Monitoring of erlotinib in pancreatic cancer patients during long time administration and comparison to a physiologically based pharmacokinetic model

2018
Cancer Chemother Pharmacol
PMCID: 5854746
PMID: 29453635
DOI: 10.1007/s00280-018-3545-4

[…] ib plasma concentration. Insert a displays the comparison of the mean observed concentration in patients, who received erlotinib to a fasted state, without any relevant co-medication to the predicted GastroPlus™ single simulation, matching the settings of the standard patient of the study. Cpeak differed by 8.5% but AUC0–24 achieved a 100% fit to the observed values, concluding that the prediction […]

library_books

Phase I study of the investigational oral mTORC1/2 inhibitor sapanisertib (TAK 228): tolerability and food effects of a milled formulation in patients with advanced solid tumours

2018
PMCID: 5812400
PMID: 29464110
DOI: 10.1136/esmoopen-2017-000291

[…] d a physical milling step following granulation to improve particle size distribution and enable automated capsule filling for scaling-up manufacturing. Initial pharmacokinetic (PK) simulations using GastroPlus (Simulations Plus, Lancaster, California, USA) suggested that milled and unmilled TAK-228 capsules dosed up to 6 mg under fasting conditions would result in similar maximum plasma concentra […]

library_books

Clinical Bioavailability of the Novel BACE1 Inhibitor Lanabecestat (AZD3293): Assessment of Tablet Formulations Versus an Oral Solution and the Impact of Gastric pH on Pharmacokinetics

2018
PMCID: 5947295
PMID: 29319935
DOI: 10.1002/cpdd.422

[…] r CSF Aβ reductions. Lanabecestat has high permeability and pH‐dependent solubility and could tentatively be considered as a Biopharmaceutical Classification System II drug. Absorption modeling using GastroPlus predicted that changes in gastric pH (up to pH 7.4) would be expected to have a negligible effect on clinical PK. This is likely driven by the relatively low dose (50 mg) and the compound's […]

library_books

Automated workflows for modelling chemical fate, kinetics and toxicity

2017
PMCID: 5745146
PMID: 28323105
DOI: 10.1016/j.tiv.2017.03.004

[…] database provides useful information on how the models were built. Furthermore, several commercial tools are available to program (Matlab, R language, Berkeley Madonna, etc.), build and use (SimCyp, gastroplus/ADMET, PkSim, ACSL/X, etc.) as well as tools that can be used without a commercial licence: MERLIN EXPO (, ), MEgen and Rvis, () COSMOS ().The coupling of a PBK model, describing the kineti […]

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GastroPlus institution(s)
Simulations Plus, Inc., Lancaster, CA, USA

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