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GastroPlus specifications

Information


Unique identifier OMICS_16038
Name GastroPlus
Software type Package/Module
Interface Graphical user interface
Restrictions to use License purchase required
Operating system Unix/Linux
Computer skills Medium
Version 9.5
Stability Stable
Maintained Yes

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  • person_outline DDDPlus Team <>

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GastroPlus in publications

 (31)
PMCID: 5892888
PMID: 29634717
DOI: 10.1371/journal.pone.0194046

[…] to assess the impact of variability associated with physiological and drug-specific parameters on the oral pk profile of sheta2 in humans, we performed virtual clinical trial simulations using gastroplus version 9.5 (simulations plus, inc., lancaster, ca), a physiologically-based pharmacokinetic (pbpk) modeling software. the oral pharmacokinetics of sheta2 were simulated by linking […]

PMCID: 5854746
PMID: 29453635
DOI: 10.1007/s00280-018-3545-4

[…] of 100 mg erlotinib q.d., 500–900 mg capecitabine b.d. and 5 mg/kg bevacizumab q.2wks. samples were analyzed by hplc and the results were compared to a pbpk model, built with the software gastroplus™ and based on calculated and literature data., the erlotinib plasma concentrations did not show any accumulation, but displayed a high inter-patient variability over the whole investigated […]

PMCID: 5745146
PMID: 28323105
DOI: 10.1016/j.tiv.2017.03.004

[…] database provides useful information on how the models were built. furthermore, several commercial tools are available to program (matlab, r language, berkeley madonna, etc.), build and use (simcyp, gastroplus/admet, pksim, acsl/x, etc.) as well as tools that can be used without a commercial licence: merlin expo (, ), megen and rvis, () cosmos ()., the coupling of a pbk model, describing […]

PMCID: 5656087
PMID: 28866268
DOI: 10.1016/j.yrtph.2017.08.019

[…] programs include berkley madonna (berkeley, ca) (n = 24), acslx (the aegis technologies group, huntsville, al) (n = 21), matlab (mathworks, inc., natick, ma) (n = 19), and r (n = 18), followed by gastroplus (simulations plus, lancaster, ca) (n = 11) and simcyp (certera, princeton, nj) (n = 10). most participants used multiple platforms.fig. 4fig. 4, pbk models include both physiological […]

PMCID: 5702897
PMID: 28748626
DOI: 10.1002/psp4.12228

[…] inclusion and 0.001 for backward deletion. the poppk model was evaluated with goodness‐of‐fit diagnostics and visual predictive checks (vpc)., the pbpk models were developed for pictilisib using gastroplus v. 8.5 (simulations plus, lancaster, ca) for the average and representative subjects from fasted, fed, and fasted state with ppi. the model development process included prospective […]


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GastroPlus institution(s)
Simulations Plus, Inc., Lancaster, CA, USA

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