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GDSC specifications


Unique identifier OMICS_03989
Alternative name Genomics of Drug Sensitivity in Cancer
Restrictions to use None
Maintained Yes


  • Primates
    • Homo sapiens


  • person_outline Mathew J. Garnett

Publication for Genomics of Drug Sensitivity in Cancer

GDSC citations


Investigation of model stacking for drug sensitivity prediction

BMC Bioinformatics
PMCID: 5872495
PMID: 29589559
DOI: 10.1186/s12859-018-2060-2

[…] We have access to four non-overlapping sources of data. (a) Drug sensitivity values for 265 compounds in the form of normalized AUC on 982 cancer cell lines supplied by GDSC [] constitute the response variable. (b) Normalized gene expression for 982 cancer cell lines, also given by GDSC [], forms one set of predictors. Once again, we use RELIEFF to screen the top 500 […]


A peptide tag specific nanobody enables high quality labeling for dSTORM imaging

Nat Commun
PMCID: 5834503
PMID: 29500346
DOI: 10.1038/s41467-018-03191-2

[…] ed. To estimate image resolution, custom written Python 2.7 (Python Software Foundation) and Fiji algorithms utilizing code from the Lama software and GDSC SMLM ImageJ plugin ( were used. NeNA localization precision and Fourier Image Resolution (FIRE) were calculated for all analyzed regions. To calculate FIRE, localization files […]


A novel heterogeneous network based method for drug response prediction in cancer cell lines

Sci Rep
PMCID: 5820329
PMID: 29463808
DOI: 10.1038/s41598-018-21622-4

[…] In this work, we propose a novel heterogeneous network-based method (HNMDRP) to predict the responses of cancer cell lines with multiple drugs based on experimentally IC50 values from the GDSC study. Here, five sub-networks are constructed: (1) cell line similarity network, which is obtained by calculating Pcc values based on cell line gene expression profiles, (2) drug similarity netw […]


Aberration corrected cryoimmersion light microscopy

Proc Natl Acad Sci U S A
PMCID: 5819432
PMID: 29358380
DOI: 10.1073/pnas.1717282115

[…] llowing us to put W2010 on top of the sample and to perform imaging at room temperature. Image processing and analysis were carried out by using Fiji (). FWHM values were measured by using the plugin GDSC SMLN after running an inverted deconvolution run for correcting for finite size of the beads using the plugin Deconvolutionlab2 (). […]


Shifting meiotic to mitotic spindle assembly in oocytes disrupts chromosome alignment

PMCID: 5797964
PMID: 29330318
DOI: 10.15252/embr.201745225

[…] channel) was first filtered using 3D Gaussian filter (radius = 2) to reduce noise and then thresholded using MaxEntropy method. aMTOCs (RFP channel) were first filtered using difference of Gaussians (GDSC libraries from Alex Herbert, University of Sussex) to increase spot‐like signals, then thresholded using MaxEntropy method. For each channel, 3D objects were segmented using the 3D ImageJ suite . […]


Systematic Review: Characteristics and Preclinical Uses of Bladder Cancer Cell Lines

PMCID: 5929350
PMID: 29732388
DOI: 10.3233/BLC-180167

[…] the reviewed human BC cell lines is summarized in (Complete information available in ). Many cell lines are now part of panels that have been characterized by different research groups. For example, Genomics of Drug Sensitivity in Cancer (GDSC) determined molecular alterations by using 20 BC cell lines to predict response to anti-cancer therapeutics []. Similarly, The Cancer Proteome Atlas (TCPA) […]


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GDSC institution(s)
Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK

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