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GeneSigDB specifications


Unique identifier OMICS_03315
Name GeneSigDB
Alternative name Gene Signature DataBase
Restrictions to use None
Version 4.0
Maintained Yes


  • Primates
    • Homo sapiens
  • Rodents
    • Mus musculus
    • Rattus norvegicus


  • person_outline GeneSigDB

Publication for Gene Signature DataBase

GeneSigDB citations


Drug repurposing for the treatment of glioblastoma multiforme

PMCID: 5704391
PMID: 29179732
DOI: 10.1186/s13046-017-0642-x

[…] lly able to rescue it [].Freely available resources are ArrayExpress [], NCBI-GEO [] and cMap [], all large public repositories of gene expression data. Moreover, tools such as DAVID [], MSigDB [] or GeneSigDB [] allow characterizing large gene lists by using pre-defined functional terms. This strategy has been found effective also for drug repositioning [, ].Recently, drug repositioning has been […]


The CINSARC signature as a prognostic marker for clinical outcome in multiple neoplasms

Sci Rep
PMCID: 5511191
PMID: 28710396
DOI: 10.1038/s41598-017-05726-x

[…] n, we removed signatures with less than 25 known genes in PRECOG database to avoid inflated scorings for very small gene sets. This filtered out 4,394 (24%) and 1,085 (37%) signatures from MSigDB and GeneSigDB, respectively. Of note, BORA (formerly known as C13orf34) was not evaluated in PRECOG and is therefore missing in both full (curated) and reduced (62 genes) CINSARC.In the database of 15,499 […]


Translating Proteomic Into Functional Data: An High Mobility Group A1 (HMGA1) Proteomic Signature Has Prognostic Value in Breast Cancer*

PMCID: 4762532
PMID: 26527623
DOI: 10.1074/mcp.M115.050401

[…] rognostic markers or cancer therapeutic targets (supplemental Table S6).Moreover, several HRS members were present in breast cancer-associated gene signatures, as evidenced by the data extracted from GeneSigDB, a curated signature database (supplemental Fig. S5). TOP2A (DNA topoisomerase 2-α) and RRM2 (ribonucleoside-diphosphate reductase subunit M2) are noteworthy examples of proteins with both a […]


Multiple sources of bias confound functional enrichment analysis of global omics data

Genome Biol
PMCID: 4561415
PMID: 26346307
DOI: 10.1186/s13059-015-0761-7

[…] support the claim that an analysis is robust [, ].Most frequently, the functional categories are identified using classification schemes such as that of the Gene Ontology (GO) consortium [] (MSigDB, GeneSigDB and Ingenuity Pathway Analysis (IPA) are other examples). Discovery that the list of regulated genes contains an overrepresentation for one or more biological ‘functions’ can identify the un […]


Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance

PLoS One
PMCID: 4493002
PMID: 26147434
DOI: 10.1371/journal.pone.0131866
call_split See protocol

[…] were collapsed into single genes and rank-ordered by signal to noise ratio. 1000 Gene set permutations were used to estimate statistical significance. Analyzed gene sets were obtained from MSigDB and GeneSigDB [,]. The comparison of gene expression profiles in dnMpl LSK cells in CD34+ cells of patients with severe aplastic anemia (SAA) and refractory cytopenia (RC) was made on the basis of the sig […]


Evaluation and validation of a robust single cell RNA amplification protocol through transcriptional profiling of enriched lung cancer initiating cells

BMC Genomics
PMCID: 4320548
PMID: 25519510
DOI: 10.1186/1471-2164-15-1129

[…] n the MCIC population, compared to the TT samples, are enriched for specific pathways, or overlap with published RNA profiles by submitting the top 100 differentially expressed genes for DAVID [] and GeneSigDB [] analysis. DAVID pathway analysis showed that MCIC UP genes were linked to cytoskeleton, ribosomal processing, glutathione transferase and, to a lesser extent, RNA splicing and tubulin (Ad […]


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GeneSigDB institution(s)
Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA
GeneSigDB funding source(s)
This work was supported by National Institutes for Health National Library of Medicine (1R01 LM010129), National Cancer Institute (1U19 CA148065), Genome Research Institute (1P50 HG004233); Dana-Farber Cancer Institute Women's Cancers Program (to A.C.C); Claudia Adams Barr foundation.

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