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Integrates diverse types of omics data across mammals to advance understanding of the genetic basis of gestation and pregnancy-associated phenotypes and to accelerate the translation of discoveries from model organisms to humans. GEneSTATION provides the data and tools to easily explore pregnancy from three complementary perspectives, EVOLUTIONARY, ORGANISMAL, and MOLECULAR, at three levels of synthesis. At the first level, individual gene pages integrate the EVOLUTIONARY, ORGANISMAL, and MOLECULAR perspectives in three easily accessible tabs, providing a comprehensive picture of the breadth of the data available for a single gene and introducing researchers to analyses and data that they have not previously considered. At the second level, individual analysis pages provide access to genome-wide information from a single perspective, such as natural selection in the human lineage, differential expression in complications of pregnancy, or protein-protein interactions among genes known to be involved in pregnancy. At the final level of synthesis, the Gene Set Analysis tool and the novel ‘SynTHy’ (Synthesis and Testing of Hypotheses) tool enable researchers to synthesize on-the-fly the many types of information available through the development and evaluation of testable hypotheses.

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GEneSTATION classification

  • Animals
    • Homo sapiens

GEneSTATION specifications

Restrictions to use:
None
Version:
GEneSTATION version 1.0

GEneSTATION support

Maintainer

Credits

Publications

  • (Kim et al., 2015) GEneSTATION 1.0: a synthetic resource of diverse evolutionary and functional genomic data for studying the evolution of pregnancy-associated tissues and phenotypes. Nucleic acids research.
    PMID: 26567549

Institution(s)

Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA; Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA; Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37235, USA; Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA

Funding source(s)

March of Dimes, as part of the March of Dimes Prematurity Research Center Ohio Collaborative

Link to literature

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