A web service allowing the integrated analysis of transcriptomic, miRNomic, genomic, and proteomic datasets. GeneTrail offers multiple statistical tests, a large number of predefined reference sets, as well as a comprehensive collection of biological categories and enables direct comparisons between the computed results. GeneTrail was designed to offer users a maximal amount of flexibility while keeping the common workflow accessible to non-expert users. This is achieved by offering a user friendly, well-documented web interface. In turn, scripting capabilities allow expert users to conduct fully automated large-scale analyses and the integration into third-party applications.