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geneXplain platform specifications


Unique identifier OMICS_33714
Name geneXplain platform
Interface Web user interface
Restrictions to use License purchase required
License Commercial
Computer skills Basic
Version 4.11
Stability Stable
Free trial Yes
Registration required Yes
Maintained Yes

geneXplain platform citations


JAK/STAT3 regulated global gene expression dynamics during late stage reprogramming process

BMC Genomics
PMCID: 5840728
PMID: 29510661
DOI: 10.1186/s12864-018-4507-2
call_split See protocol

[…] AVID) []. We summarized all similar sub-GO terms and pathways into an overarching term, and p-values are shown for the representative terms. Principle component analysis (PCA) was performed using the GeneXplain platform ( […]


Computational master regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin 3

BMC Med Genomics
PMCID: 5836833
PMID: 29504919
DOI: 10.1186/s12920-018-0330-5

[…] utlin-3.Fig. 4We performed gene set enrichment analysis (GSEA) of the obtained three gene expression profiles of differences between sensitive and insensitive lung cancer cell lines. For that we used geneXplain platform and applied the pathways ontology of TRANSPATH® database. The most enriched pathways are presented in the Additional file : Table S3.1 and S3.2 as well as in Fig. .Fig. 5In the Fig […]


Nucleotide patterns aiding in prediction of eukaryotic promoters

PLoS One
PMCID: 5687710
PMID: 29141011
DOI: 10.1371/journal.pone.0187243

[…] he transcription factor binding sites (TFBS) in promoters and the UTRs of high-confidence rice genes in the regions of -1000 +1000 around TSS were investigated with MATCH algorithm [] incorporated in geneXplain platform ( MATCH uses the TRANSFAC database [] comprising 764 plant position weight matrices (PWM) with a strict similarity score threshold of 0.95. MATCH scans the targ […]


The pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury

PMCID: 5746105
PMID: 29296203
DOI: 10.18632/oncotarget.21201

[…] lecular functions, metabolic and signaling pathways and transcription factor classification. For each ontological term the p-value and the expected and actual number of hits were calculated using the GeneXplain platform version 3.0. A biological process was considered significant at a p-value <0.05 and the terms were used for further analysis. In addition, significantly enriched gene ontology term […]


Type I IFN and not TNF, is Essential for Cyclic Di nucleotide elicited CTL by a Cytosolic Cross presentation Pathway

PMCID: 5552247
PMID: 28754303
DOI: 10.1016/j.ebiom.2017.07.016
call_split See protocol

[…] nt Technologies, USA). Microarray data were generated from Affymetrix microarrays. A minimum of triplicate samples were analyzed to reach statistical significance.The CEL files were uploaded into the geneXplain platform () for the following analysis: microarray measurements were normalized using Robust Multi-array Averaging (RMA) () in the package oligo (). Differentially expressed genes (DEGs) we […]


RNA isolation from precision cut lung slices (PCLS) from different species

BMC Res Notes
PMCID: 5343379
PMID: 28274266
DOI: 10.1186/s13104-017-2447-6

[…] ratios) as a function of A (mean average). Outliers were detected by computing Hoeffding’s statistic Da on the joint distribution of A and M for each array. The normalized data were imported into the geneXplain platform ( to perform a principal component analysis (PCA). The geneXplain platform was further used to detect differentially expressed genes for all samples wit […]


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geneXplain platform institution(s)
geneXplain GmbH, Wolfenbüttel, Germany

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