Programmable nucleases – including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and RNA-guided engineered nucleases (RGENs) derived from the bacterial clustered regularly interspaced short palindromic repeat (CRISPR)-Cas…
Programmable nucleases – including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and RNA-guided engineered nucleases (RGENs) derived from the bacterial clustered regularly interspaced short palindromic repeat (CRISPR)-Cas (CRISPR-associated) system – enable targeted genetic modifications in cultured cells, as well as in whole animals and plants. The value of these enzymes in research, medicine and biotechnology arises from their ability to induce site-specific DNA cleavage in the genome, the repair (through endogenous mechanisms) of which allows high-precision genome editing.
Allows side-by-side correlative analysis of scoring functions. The CRISPR Guide…
Allows side-by-side correlative analysis of scoring functions. The CRISPR Guide Picker mode is an addition to the DESKGEN Cloud Platform. It allows user to visualize data from four sgRNA design…
Predicts recognition helices for C2H2 zinc fingers that bind to specific target…
Predicts recognition helices for C2H2 zinc fingers that bind to specific target DNA sites. ZiF-Predict is based on artificial neural network using an exhaustive dataset of zinc finger proteins (ZFP)…
Predicts high throughput of optimal zinc finger protein for 9 bp DNA sequences…
Predicts high throughput of optimal zinc finger protein for 9 bp DNA sequences of choice. ZifNN is inspired from an ensemble machine learning approach, and incorporates the predictions made by 100…
Allows for the design of CRISPR guide RNA libraries that can be used to edit…
Allows for the design of CRISPR guide RNA libraries that can be used to edit coding and noncoding genomic regions. GuideScan produces high-density sets of guide RNAs (gRNAs) for single- and…