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Genotype imputation has been widely adopted in the postgenome-wide association studies (GWAS) era. Owing to its ability to accurately predict the genotypes of untyped variants, imputation greatly boosts variant density, allowing fine-mapping studies of GWAS loci and large-scale meta-analysis across different genotyping arrays.
(Liu et al., 2015) Systematic assessment of imputation performance using the 1000 Genomes reference panels. Brief Bioinform.