Maps sequence variants to protein structures from the Protein Data Bank (PDB), and further to protein–protein, protein–nucleic acid, protein–compound, and protein–metal ion binding sites. GenProBiS enables detection of sequence variants within a protein binding site. It allows visual exploration of interactions, or loss of interactions, of a specific mis-sense mutation with a specific ligand. The tool permits focused laboratory experiments based on targeted hypotheses in several research fields including human, veterinary medicine, animal and plant breeding.
National Institute of Chemistry, Ljubljana, Slovenia; University of Primorska, Faculty of Mathematics, Natural Sciences and Information Technologies, Koper, Slovenia; Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia
GenProBiS funding source(s)
Supported by the Slovenian Research Agency (P1-0002 and P4-0220) and by the Slovenian Research Agency.