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Germline single nucleotide polymorphism identification software tools | High-throughput sequencing data analysis

Germline single nucleotide polymorphism identification software tools | High-throughput sequencing data analysis

Meaningful analysis of next-generation sequencing (NGS) data, which are produced extensively by genetics and genomics studies, relies crucially on the accurate calling of SNPs and genotypes. Recently developed statistical methods both improve and quantify the considerable uncertainty associated with genotype calling, and will especially benefit the growing number of studies using low- to medium-coverage data.

Source text:
(Nielsen et al., 2011) Genotype and SNP calling from next-generation sequencing data. Nat Rev Genet.

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