GET_HOMOLOGUES specifications


Unique identifier OMICS_05365
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS
Computer skills Advanced
Stability Stable
Maintained Yes


  • Archaebacteria
  • Eubacteria


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PMCID: 5809883

[…] 30], we decided to involve them in this study to acquire richer information on the evolution and forces for genome changes of the group due to their relatively unique living strategies., the program get_homologues v3.0.3 [31], with three popular clustering algorithms, i.e. bidirectional best hit (bdbh), cogtriangles [32] and orthomcl [33], was used for clustering orthologous genes […]

PMCID: 5306281

[…] genes include several examples of unknown functions, specific transposases or proteins such as prolamins, self-incompatibility s1 or c1 proteins., the results presented in this paper illustrate how get_homologues-est can be used to analyze plant pan-genomes from either genomic sequences or expressed tags. our approach overcomes some intrinsic caveats, such as incomplete sequences or transcripts […]

GET_HOMOLOGUES institution(s)
Estación Experimental de Aula Dei (EEAD-CSIC), Zaragoza, Spain; Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico


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This suit allows users to calculate pan- and core-genome for prokaryote and eukaryote genomes. It is relatively easy to use and it comes with good tutorials. It allows you to to use different algorithm to calculate orthologues genes, which I like. Moreover is periodically patched and new features are added. Moreover, it is quite interesting the features of looking for syntenic genes only, or look for orthologues intergenic regions. I would only have like to see OrthonFinder implemented and some more visualization tools for syntenic orthologues genes and pan- core-genomes. Overall it is a relly good and flexible tool! Highly recommendable.