Allows the evaluation of genome assemblies through its tools and pre-computed analyses. The strength of this browser is the ability to navigate an up to date assembly and identify problematic regions and assist in strategizing potential solutions for these issues. This facilitates the improvement of overall assemblies to a “gold” standard for release as reference genomes. These analyses include: a wide variety of sequence alignments, comparative analyses of multiple genome assemblies, and consistency with optical and other physical maps. gEVAL highlights allelic variations, regions of low complexity, abnormal coverage, and potential sequence and assembly errors, and offers strategies for improvement. While gEVAL focuses primarily on sequence integrity, it can also display arbitrary annotation including Ensembl or TrackHub sources. We provide gEVAL web sites for many human, mouse, zebrafish and chicken assemblies to support the Genome Reference Consortium, and gEVAL is also downloadable to enable its use for any organism and assembly.
Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK; East Anglian Medical Genetics Centre, Cambridge University Hospitals, NHS Foundation Trust, Cambridge, UK; National Institute of Agricultural Botany, Cambridge, UK