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GLAD4U specifications


Unique identifier OMICS_21981
Alternative name Gene List Automatically Derived For You
Interface Web user interface
Restrictions to use None
Output format CSV,TXT
Programming languages C, Perl
License GNU General Public License version 3.0
Computer skills Basic
Version 2.5
Stability Stable
Maintained Yes


  • person_outline Bing Zhang <>

Additional information

Publication for Gene List Automatically Derived For You

GLAD4U citations


Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole genome sequencing

PMCID: 5647344
PMID: 29044207
DOI: 10.1038/s41467-017-01194-z

[…] using the webgestalt online tool. for disease association analysis, webgestalt uses disease terms downloaded from pharmgkb and genes associated with individual disease terms were inferred using glad4u (gene list automatically derived for you). human genome data (hsapiens_genome) was used as reference set, the benjamini-hochberg multiple test was used to adjust for multiple testing. […]


Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis

PMCID: 5549357
PMID: 28789679
DOI: 10.1186/s12920-017-0286-x

[…] the following criteria: 1) fully available in web service platform and 2) requiring only the disease name for gene prioritization. under these conditions we found 12 methods: biograph [], candid [], glad4u [], polysearch [], cipher [], guildify [], disgenet [], geneprospector [], genie [], snps3d [], genedistiller [] and metaranker []. the following methods: cipher, guildify and disgenet […]


Genome wide signatures of complex introgression and adaptive evolution in the big cats

PMCID: 5517113
PMID: 28776029
DOI: 10.1126/sciadv.1700299

[…] on each method using webgestalt (), with the human genome as the reference, and searching the following data bases: gene ontology (, ), pathway commons (), kegg pathway (, ), disease (, and phenotypes (). we used a significance threshold of 0.05 and a multiple testing correction (benjamini-hochberg) to control for false discovery. within genes […]


Metastatic triple negative breast cancer patient with TP53 tumor mutation experienced 11 months progression free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events

PMCID: 5495034
PMID: 28679691
DOI: 10.1101/mcs.a001677

[…] are presented in supplemental table 3. among the differentially expressed genes, 410 could be assigned as “breast cancer–relevant” based on a list of 433 breast cancer–relevant genes generated using glad4u webservice. the 10 most up- and down-regulated breast cancer relevant genes as defined by this method are presented in supplemental table 4. kegg pathway enrichment analysis […]


BALR 6 regulates cell growth and cell survival in B lymphoblastic leukemia

PMCID: 4688921
PMID: 26694754
DOI: 10.1186/s12943-015-0485-z

[…] the go database, were significantly dysregulated in balr-6 knockdown cell lines, including cell death and cell proliferation (fig. ). disease associated enrichment analysis, which was inferred using glad4u, showed an enrichment of genes known to be dysregulated in various disease states (fig. ). of the 38 significantly associated disease states, 14 were of leukemic origin. transcription factor […]


Increased Transcript Complexity in Genes Associated with Chronic Obstructive Pulmonary Disease

PMCID: 4610675
PMID: 26480348
DOI: 10.1371/journal.pone.0140885

[…] and ) [, ]. literature reviews contributed the majority of the gene list for copd, as these represent the best form of manual curation for further analysis. we did not include the pubmed text-miner, glad4u, and the snp database, snp4disease in our gene list generation, although we did use these resources in a confirmatory manner (, ) [, ]., to assess transcript complexity in other complex […]

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GLAD4U institution(s)
Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Advanced Computing Center for Research & Education, Vanderbilt University, Nashville, TN, USA; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA
GLAD4U funding source(s)
Supported by the National Institutes of Health (NIH)/ National Institute of General Medical Sciences (NIGMS) through grant R01GM088822; the NIH/National Cancer Institute (NCI) through grant U54CA113007; and the NIH/ National Institute of Mental Health (NIMH) through grant P50MH078028.

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