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Enables proteome-wide discovery of O-glycan sites using ‘bottom-up’ ETD-based mass spectrometric analysis. GlycoDomain Viewer is a genetic engineering approach that uses human cell lines to simplify O-glycosylation (SimpleCells). The method was implemented on 12 human cell lines from different organs. It presents a first map of the human O-glycoproteome with almost 3000 glycosites in over 600 O-glycoproteins as well as an improved NetOGlyc4.0 model for prediction of O-glycosylation.

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GlycoDomain Viewer classification

GlycoDomain Viewer specifications

Software type:
Package
Restrictions to use:
None
Stability:
Stable
Interface:
Web user interface
Computer skills:
Basic

Publications

  • (Steentoft et al., 2013) Precision mapping of the human O‐GalNAc glycoproteome through SimpleCell technology. The EMBO Journal.
    DOI: 10.1038/emboj.2013.79

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Documentation

Credits

Institution(s)

Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine and School of Dentistry, University of Copenhagen, Copenhagen, Denmark; Center for Biological Sequence Analysis, Department of Systems Biology Technical University of Denmark, Lyngby, Denmark; IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark

Funding source(s)

This work was supported by Kirsten og Freddy Johansen Fonden, A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til Almene Formaal, The Carlsberg Foundation, The Novo Nordisk Foundation, The Danish Research Councils, a programme of excellence from the University of Copenhagen, the Sino-Danish Breast Cancer Centre, and The Danish National Research Foundation (DNRF107).

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