GMDR statistics

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GMDR specifications


Unique identifier OMICS_24673
Alternative name Generalized Multifactor Dimensionality Reduction
Software type Application/Script
Interface Command line interface, Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages Java, Perl
License GNU General Public License version 2.0
Computer skills Advanced
Version 0.9
Stability Beta
Java SE Runtime Environment
Maintained Yes



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  • person_outline Xiang-Yang Lou <>
  • person_outline Guo-Bo Chen <>

Publications for Generalized Multifactor Dimensionality Reduction

GMDR in publications

PMCID: 5918459
PMID: 29697366
DOI: 10.1186/s12920-018-0343-0

[…] interactions (ggis) are a known cause of missing heritability. multifactor dimensionality reduction (mdr) is one of most commonly used methods for ggi detection. the generalized multifactor dimensionality reduction (gmdr) method is an extension of mdr method that is applicable to various types of traits, and allows covariate adjustments. our previous fuzzy mdr […]

PMCID: 5904126
PMID: 29666375
DOI: 10.1038/s41398-018-0130-x

[…] adjusted for same covariates under the additive model., to estimate the epistatic contribution of variants in six nachr subunit genes to nd, we performed snp-by-snp interaction analysis using the gmdr-gpu program developed by our group,, performing an exhaustive search of all combinations containing 2–5 snps each. the best interaction model was determined according to the following three […]

PMCID: 5915141
PMID: 29707133
DOI: 10.18632/oncotarget.24801

[…] of ultrasound, the patients were stratified into three groups: non-plaque group, vulnerable plaque (vp) group and stable plaque (sp) group. furthermore, gene-gene interactions were analyzed using generalized multifactor dimensionality reduction (gmdr) methods., the rs1131882, rs2317676, and rs16863323 three-loci interactions may confer a higher risk of carotid plaque vulnerability, and might […]

PMCID: 5895403
PMID: 29595641
DOI: 10.1097/MD.0000000000010160

[…] g × e interaction, psychiatric interviews, self-report questionnaires for cht, and genotyping for bdnf val66met were carried out on 201 schizophrenic patients. g × e interactions were analyzed by generalized multifactor dimensionality reduction (gmdr)., among all patients, 11.9%, 19.4%, 23.4%, 26.4%, and 73.6% reported emotional abuses, physical abuses (pa), sexual abuses (sa), emotional […]

PMCID: 5835279
PMID: 29670668
DOI: 10.1155/2018/1371425

[…] score below 0.9) and preeclampsia was also calculated by logistic regression in snpstat software. the results of the logistic regression were presented as ors and 95% ci and p values., moreover, the generalized multifactor dimensionality reduction (gmdr, v0.9; [, ] analysis was used to calculate the interaction among five studied polymorphisms (−1607 1g/2g mmp1 […]

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GMDR institution(s)
Institute of Bioinformatics and Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China; Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, China; Institute of Computer Application Technology, College of Computer Science and Technology, Zhejiang University of Technology, Hangzhou, China; Queensland Brain Institute, University of Queensland, St Lucia, QLD, Australia; Sir Run Run Shaw Hospital and Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, China; Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, LA, USA
GMDR funding source(s)
Supported in part by National Institute of Health Grant R01 DA025095 and National Science Foundation DMS1462990, the National Basic Research Programs of China (973 Programs) 2011CB109306, and the National Natural Science Foundation 31271608 and 31470083.

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