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GOAT specifications


Unique identifier OMICS_22097
Alternative name Gene Ontology Analysis Tool
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
Computer skills Advanced
Stability No
Maintained No


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Publication for Gene Ontology Analysis Tool

GOAT citations


RNA seq based transcriptomic map reveals new insights into mouse salivary gland development and maturation

BMC Genomics
PMCID: 5112738
PMID: 27852218
DOI: 10.1186/s12864-016-3228-7

[…] e : Table S4). To gain a better understanding of the underlying biological functions and pathways associated with the adult salivary gland gene signature, we utilized ClueGO [], which is a functional gene ontology analysis tool that integrates several gene-set enrichment databases, including the Kyoto Encyclopedia of Genes and Genomes (KEGG), REACTOME pathway database annotations, and the GO Conso […]


Transcriptome based reconstructions from the murine knockout suggest involvement of the urate transporter, URAT1 (slc22a12), in novel metabolic pathways

PMCID: 4522937
PMID: 26251846
DOI: 10.1016/j.bbrep.2015.07.012

[…] ndicated that other proteins may be equally if not more important uric acid transporters than URAT1, and because a number of other URAT1 substrates have been identified, we used, as a first step, the gene ontology analysis tool AmiGO (http://amigo1.geneontology.org/; accessed February 11th, 2015) to quantify the enrichment of general functional annotations among the differentially expressed genes. […]


A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53 mediated inhibition of pro survival activities of the activating transcription factor 4

PMCID: 4260727
PMID: 25375376
DOI: 10.1038/cddis.2014.469

[…] To study the response of cells to stress induced by inhibition of the mitochondrial ETC complex III, we monitored by mRNA-seq the transcriptome changes following myxothiazol treatment. We used the gene ontology analysis tool DAVID to assess the enrichment of transcripts corresponding to functional groups within the list of differentially expressed genes relative to their representation within t […]


Hierarchical Partitioning of Metazoan Protein Conservation Profiles Provides New Functional Insights

PLoS One
PMCID: 3942430
PMID: 24594619
DOI: 10.1371/journal.pone.0090282

[…] vation, in addition to studying protein families enriched within the different organism subdivisions.We use the conservation profiles to hierarchically partition the set of proteins, and then apply a gene ontology analysis tool, GOrilla (Eden et al. ). This enables the elucidation of relations between sequence conservation, function, and the consistency of conservation profiles with the tree of li […]


The Carboxy Terminal Domain of Dictyostelium C Module Binding Factor Is an Independent Gene Regulatory Entity

PLoS One
PMCID: 2661138
PMID: 19343174
DOI: 10.1371/journal.pone.0005012

[…] ntial expression of these genes was confirmed. In order to match biological functions to the list of differentially regulated genes, we performed a gene ontology (GO) term enrichment analysis using a gene ontology analysis tool (GOAT) , . A list of GO term enrichments for genes differentially expressed in the CbfA mutant is deposited in . Our analysis suggests that CbfA positively regulates biolog […]


Expressed sequence tags from Peromyscus testis and placenta tissue: Analysis, annotation, and utility for mapping

BMC Genomics
PMCID: 2443383
PMID: 18577228
DOI: 10.1186/1471-2164-9-300

[…] he basis of a 1-tailed test at P ≤ 0.05.To determine what biological processes were associated with the identified Peromycsus ESTs, we analyzed the mouse and rat homologous gene lists using an online gene ontology analysis tool, FatiGO []. We assigned gene ontologies using the fourth level of increasing specificity. […]

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GOAT institution(s)
Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

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