Most drug targets are receptors expressed on the cell surface. Approximately half of those are G protein-coupled receptors (GPCRs), a class of seven transmembrane domain receptors. GPCRs remain the most pursued drug targets by academic and pharmaceutical groups (Lagerström…
GLASS
Data

GLASS GPCR-Ligand Association

Aims to provide a comprehensive, manually-curated resource for experimentally…

Aims to provide a comprehensive, manually-curated resource for experimentally validated GPCR-ligand associations. A new text-mining algorithm was proposed to collect GPCR-ligand interactions from the…

GPCR-OKB
Data

GPCR-OKB GPCR-Oligomerization Knowledge Base

A system that supports browsing and searching for GPCR oligomer data. Such data…

A system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature. While focused on GPCR oligomers, GPCR-OKB is seamlessly connected to GPCRDB,…

Human-gpDB
Data

Human-gpDB

A database which currently holds information about 713 human GPCRs, 36 human…

A database which currently holds information about 713 human GPCRs, 36 human G-proteins and 99 human effectors. The collection of information about the interactions between these molecules was done…

GtoPdb
Data

GtoPdb IUPHAR/BPS Guide to PHARMACOLOGY

Provides expert-curated molecular interactions between successful and potential…

Provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome. The information in the database is presented at two levels: the initial…

PDSP Ki…
Data

PDSP Ki database

A unique resource in the public domain which provides information on the…

A unique resource in the public domain which provides information on the abilities of drugs to interact with an expanding number of molecular targets. The Ki database serves as a data warehouse for…

BAO-GPCR
Terminology

BAO-GPCR GPCR ontology

Facilitates integration and aggregation of GPCR-targeting drugs and demonstrate…

Facilitates integration and aggregation of GPCR-targeting drugs and demonstrate its application to classify and analyze a large subset of the PubChem database. The GPCR ontology, based on previously…

GPCRDB
Data

GPCRDB G protein-coupled receptors database

A molecular-class information system that collects, combines, validates and…

A molecular-class information system that collects, combines, validates and stores large amounts of heterogenous data on G protein-coupled receptors (GPCRs). The GPCRDB contains data on sequences,…

gpDB
Data

gpDB

A publicly accessible, relational database of G-proteins and their interactions…

A publicly accessible, relational database of G-proteins and their interactions with GPCRs and effector molecules. The sequences are classified according to a hierarchy of different classes, families…

GDD
Data

GDD GPCR Decoy Database

A G protein-coupled receptor (GPCR) ligand library (GLL) for 147 targets,…

A G protein-coupled receptor (GPCR) ligand library (GLL) for 147 targets, selecting for each ligand 39 decoy molecules, collected in the GPCR Decoy Database (GDD). Decoys were chosen ensuring a…

GLIDA
Data

GLIDA GPCR-LIgand DAtabase

A public GPCR-related chemical genomics database that is primarily focused on…

A public GPCR-related chemical genomics database that is primarily focused on the integration of information between GPCRs and their ligands. It provides interaction data between GPCRs and their…

PubChem
Data

PubChem

A public repository for information on chemical substances and their biological…

A public repository for information on chemical substances and their biological activities. Since launched in 2004 as a component of the Molecular Libraries Roadmap Initiatives of the US National…

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