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Protocols

GPCRDB specifications

Information


Unique identifier OMICS_07192
Name GPCRDB
Alternative names G protein-coupled receptors database, GPCR-DB, GPCRdb
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Not allowed
Maintained Yes
Wikipedia https://en.wikipedia.org/wiki/G_protein-coupled_receptors_database

Maintainers


  • person_outline GPCRDB Team
  • person_outline David Gloriam

Publications for G protein-coupled receptors database

GPCRDB citations

 (60)
call_split

Gs  versus Golf dependent functional selectivity mediated by the dopamine D1 receptor

2018
Nat Commun
PMCID: 5799184
PMID: 29402888
DOI: 10.1038/s41467-017-02606-w
call_split See protocol

[…] on the crystal structure of β2AR-Gs complex (PDB: 3SN6) bound to a full agonist BI-167107. The template (β2AR)—target (D1R) sequence alignment was extracted from G-protein-coupled receptor database (GPCRdb). The regions that do not have a template in the β2AR structure were not modeled. Five homology models for each of D1R-Gs and D1R-Golf complex were generated using MODELLER (version 9.17) and t […]

library_books

Pharmacogenomics of GPCR Drug Targets

2018
Cell
PMCID: 5766829
PMID: 29249361
DOI: 10.1016/j.cell.2017.11.033

[…] pulations. We extracted polymorphism data for the coding-region of the 108 GPCR drug targets and GPCRs that reached clinical trials (n = 66) via their respective Ensembl transcript IDs as used in the GPCRdb (). Minor Allele frequencies (MAFs) were calculated as the ratio of allele counts of the less frequent allele to the total number of alleles at that locus. Each variant was mapped to its respec […]

library_books

Engineering cell sensing and responses using a GPCR coupled CRISPR Cas system

2017
Nat Commun
PMCID: 5738360
PMID: 29263378
DOI: 10.1038/s41467-017-02075-1

[…] The phylogenetic tree in Fig.  was constructed using GPCRdb, . Human GPCRs from the Swiss-Prot database were used as reference, without any selection for G protein preference. One GPCR from each family of Class A/Rhodopsin Family GPCRs was used to const […]

library_books

The 2018 Nucleic Acids Research database issue and the online molecular biology database collection

2017
Nucleic Acids Res
PMCID: 5753253
PMID: 29316735
DOI: 10.1093/nar/gkx1235

[…] cificity, and STCRDab () which collects and curates structural information, linking to and allowing searches against a wide variety of structural, sequence and functional data. The returning database GPCRdb (), for G protein-coupled receptors, majors on carefully made homology models and mapping receptors to ligands.Important updates in the metabolic and signalling section include the human metabo […]

library_books

GPCRdb in 2018: adding GPCR structure models and ligands

2017
Nucleic Acids Res
PMCID: 5753179
PMID: 29155946
DOI: 10.1093/nar/gkx1109

[…] Figure shows RMSD values of database/server homology models calculated directly upon release of the first structure for four GPCRs. The GPCRdb homology models have the best average RMSD values in all four categories: overall (2.8 Å), 7TM (2.3 Å), ligand site (1.8 Å) and ECL2 (3.7 Å). Among other databases with pre-generated models (bl […]

library_books

Visualizing the GPCR Network: Classification and Evolution

2017
Sci Rep
PMCID: 5686146
PMID: 29138525
DOI: 10.1038/s41598-017-15707-9

[…] ound that these clusters spread widely in the phylogenetic tree of Fig. . In general, we believe that predictions from distance-based methods are more consistent with the functional classification of GPCRdb than those from character-based methods. The two-dimensional projection of sequence locations by MDS in Fig.  basically gives the same prediction as that in Fig. , except that a higher dimensio […]

Citations

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GPCRDB institution(s)
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
GPCRDB funding source(s)
Supported by the Lundbeck Foundation [R163-2013-16327]; the European Research Council [DE-ORPHAN 639125]; the Augustinus Foundation [15-2818]; and the COST Action CM1207 ‘GLISTEN’.

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