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Glycosylphosphatidylinositol anchor attachment detection software tools | Post-translational modification data analysis

Several eukaryotic proteins associated to the extracellular leaflet of the plasma membrane carry a Glycosylphosphatidylinositol (GPI) anchor, which is linked to the C-terminal residue after a proteolytic cleavage occurring at the so called ω-site. Computational methods were developed to discriminate proteins that undergo this post-translational modification starting from their aminoacidic sequences.

Source text:
(Pierleoni et al., 2008) PredGPI: a GPI-anchor predictor. BMC Bioinformatics.

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big-Pi plant
A program for the prediction of compatibility of query protein C-termini with the plant GPI lipid anchor motif requirements. Validation tests show that the sensitivity for transamidase targets is approximately 94%, and the rate of false positive prediction is about 0.1%. Thus, the big-Pi predictor can be applied as unsupervised genome annotation and target selection tool. The program is also suited for the design of modified protein constructs to test their GPI lipid anchoring capacity.
big-Pi predictor
Evaluates the degree of presence of the C-terminal sequence signal in a query proprotein sequence based on sequence properties extracted from a learning set. big-Pi predictor allows large-scale database searches for potentially Glycosylphosphatidylinositol (GPI)-anchored protein. It predicts GPI modification sites in precursor sequences. The software integrates terms evaluating amino acid type preferences at given motif positions but also terms judging the conservation of physical properties in the query sequence which represent correlation between few or many motif positions.
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