GraBCas statistics

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Citations per year

Number of citations per year for the bioinformatics software tool GraBCas

Tool usage distribution map

This map represents all the scientific publications referring to GraBCas per scientific context
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Associated diseases

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GraBCas specifications


Unique identifier OMICS_01674
Name GraBCas
Software type Package/Module
Interface Graphical user interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Java
Computer skills Medium
Stability Stable
Maintained Yes


No version available

Publication for GraBCas

GraBCas citations


Interferon regulatory factor 8 regulates caspase 1 expression to facilitate Epstein Barr virus reactivation in response to B cell receptor stimulation and chemical induction

PLoS Pathog
PMCID: 5794192
PMID: 29357389
DOI: 10.1371/journal.ppat.1006868
call_split See protocol

[…] Potential caspase cleavage sites were searched for all the EBV protein sequences using PeptideCutter ( and the GraBCas software [,]. […]


The linear ubiquitin chain assembly complex regulates TRAIL‐induced gene activation and cell death

PMCID: 5412822
PMID: 28258062
DOI: 10.15252/embj.201695699

[…] o the apparent molecular weight of the cleavage fragment(s) observed, we narrowed down the cleavage sites within a region spanning approximately amino acids 325–400 (Fig A and C). Within this region, GrabCas (Backes et al, ) predicted two potential caspase‐8 cleavage sites, D348 and D387. In K562 HOIP KO cells reconstituted with HOIP D348A, the higher N‐terminal fragment band was still detected wh […]


Caspase 1 Promotes Epstein Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells

PLoS Pathog
PMCID: 3795028
PMID: 24130483
DOI: 10.1371/journal.ppat.1003664

[…] Putative caspase cleavage sites were searched in the BPLF1 amino acid sequence using the GraBCas software . Sites with the highest probability of cleavage were identified by setting the cut-off scores to >15. […]


PROSPER: An Integrated Feature Based Tool for Predicting Protease Substrate Cleavage Sites

PLoS One
PMCID: 3510211
PMID: 23209700
DOI: 10.1371/journal.pone.0050300

[…] s. A second issue is that only PeptideCutter , PoPS and SitePrediction were implemented to model and predict substrate cleavage sites for more than one protease family. For instance, CasPredictor , GraBCas and Cascleave can only be used to predict cleavage sites of caspases/granzyme B, but it is not feasible to apply them to predict cleavage sites of other proteases. The third issue is how to […]


Prediction of Protein Cleavage Site with Feature Selection by Random Forest

PLoS One
PMCID: 3445488
PMID: 23029276
DOI: 10.1371/journal.pone.0045854

[…] ctions of cleavage sites of the human proteasome , .Besides the three methods mentioned above, most other tools are proteinase specific, such as GPS-CCD for the prediction of calpain cleavage sites , GraBCas for the prediction of sites cleaved by granzyme B and caspases and CaSPredictor for caspase substrate prediction . Therefore, these tools are limited in applicability. In this work, we develo […]


Developing a powerful In Silico tool for the discovery of novel caspase 3 substrates: a preliminary screening of the human proteome

BMC Bioinformatics
PMCID: 3324375
PMID: 22269041
DOI: 10.1186/1471-2105-13-14

[…] ing cleavage site scoring matrices (CSSM). PeptideCutter [] is another tool that was designed with the objective of predicting cleavage sites for a wide range of proteases including various caspases. GraBCas [] is a tool that uses a position specific scoring matrix for caspases 1-9 and granzyme B, based on substrate specificities that were determined by positional scanning of synthetic peptides. C […]

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GraBCas institution(s)
Department of Human Genetics, Medical School, University of Saarland Homburg/Saar, Germany; Center for Bioinformatics, University of Saarland, Saarbrücken, Germany
GraBCas funding source(s)
A grant of the Center of Bioinformatics/Saarbrücken supported by the Deutsche Forschungsgemeinschaft; a grant from the Deutsche Krebshilfe (10-1966-Me4)

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