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GRASP specifications

Information


Unique identifier OMICS_04630
Name GRASP
Alternative name Genome-Wide Repository of Associations between SNPs and Phenotypes
Restrictions to use None
Version 2.0
Maintained Yes

Taxon


  • Primates
    • Homo sapiens

Publication for Genome-Wide Repository of Associations between SNPs and Phenotypes

GRASP citations

 (4)
library_books

Using DIVAN to assess disease/trait associated single nucleotide variants in genome wide scale

2017
BMC Res Notes
PMCID: 5663107
PMID: 29084591
DOI: 10.1186/s13104-017-2851-y

[…] ith thousands of diseases and traits. Databases have been developed to store those SNPs such as the Association Results Browser (ARB) (https://www.ncbi.nlm.nih.gov/projects/gapplus/sgap_plus.htm) and Genome-Wide Repository of Associations Between SNPs and Phenotypes (GRASP) [].An important finding from these studies is that most of the identified SNPs fall into the non-coding regions []. Unlike co […]

library_books

Predicting the impact of non coding variants on DNA methylation

2017
Nucleic Acids Res
PMCID: 5499808
PMID: 28334830
DOI: 10.1093/nar/gkx177

[…] (Materials and Methods), all the validated SNPs were scored higher by CpGenie (Figure ).We further applied CpGenie on two much larger GWAS SNPs and eQTL datasets (), one with 78 613 eQTLs from GRASP (Genome-Wide Repository of Associations between SNPs and Phenotypes) () and one with 12 296 disease-associated SNPs from the US National Human Genome Research Institute's GWAS Catalog (). For each data […]

library_books

The single nucleotide variant rs12722489 determines differential estrogen receptor binding and enhancer properties of an IL2RA intronic region

2017
PLoS One
PMCID: 5325477
PMID: 28234966
DOI: 10.1371/journal.pone.0172681

[…] As a case study, we considered IL2RA locus, which was one of the first to emerge from early GWAS as an autoimmunity risk factor []. We extracted SNP-disease association data from the Genome-Wide Repository of Associations between SNPs and phenotypes (GRASP) [] and filtered SNPs significantly associated (P < 0.001) with more than one autoimmune disease. The resulting list contained […]

library_books

Gene and Network Analysis of Common Variants Reveals Novel Associations in Multiple Complex Diseases

2016
Genetics
PMCID: 5068862
PMID: 27489002
DOI: 10.1534/genetics.116.188391

[…] nalysis was performed using the HINT interaction network (). Runs that had multiple P-values ≤0.05 of varying size k in the permutation test were further studied, for example, by annotation using the Genome-wide Repository of Associations between SNPs and Phenotypes (GRASP) GWA study catalog () to determine significance of the genes in previous GWA studies, along with functional annotations and li […]

Citations

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GRASP institution(s)
Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, The Framingham Heart Study, Framingham, MA, USA

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