Predicts functions of cis-regulatory regions. Many coding genes are well annotated with their biological functions. Non-coding regions typically lack such annotation. GREAT assigns biological meaning to a set of non-coding genomic regions by analyzing the annotations of the nearby genes. Thus, it is particularly useful in studying cis functions of sets of non-coding genomic regions. Cis-regulatory regions can be identified via both experimental methods (e.g. ChIP-seq) and by computational methods (e.g. comparative genomics).
Department of Developmental Biology, Stanford University, Stanford, CA, USA, Department of Computer Science, Stanford University, Stanford, CA, USA and Department of Electrical Engineering, Stanford University, Stanford, CA, USA