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GUItars specifications


Unique identifier OMICS_14894
Name GUItars
Software type Package/Module
Interface Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages MATLAB
Computer skills Medium
Version 3.0
Stability Stable
Maintained Yes




No version available



  • person_outline Taosheng Chen

Publication for GUItars

GUItars citations


Transcription factor ZNF148 is a negative regulator of human muscle differentiation

Sci Rep
PMCID: 5557752
PMID: 28811660
DOI: 10.1038/s41598-017-08267-5

[…] system (TTP Labtech, Cambridge, MA). Intensity, area and count of nuclei, and MHC-positive cells were measured with the Cellista program. An SSMD-based algorithm on a graphical user interface, termed GUItars, for analysis of high-throughput RNA interference screening was used for statistically evaluating quality controls and effects of the test siRNAs. Hits were identified as putative enhancers (S […]


PI4K beta and MKNK1 are regulators of hepatitis C virus IRES dependent translation

Sci Rep
PMCID: 4555030
PMID: 26323588
DOI: 10.1038/srep13344
call_split See protocol

[…] is <0.8. An impact of target-specific siRNA (four siRNA per target) on infection with HCVcc was identified in a tertiary screen using the method of strictly standardized mean differences (SSMD) using GUItars software. A target gene with specific impact on HCVcc was considered a hit if at least two individual siRNAs impairs HCVcc infection with an SSMD < =−1.645 (“fairly strong” inhibition) and abs […]


Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti Malarial Compounds

PLoS One
PMCID: 4404333
PMID: 25894322
DOI: 10.1371/journal.pone.0123598

[…] . Plates were dried overnight, 100 μL of scintillation fluid were added, and plates were then sealed and read on a TopCount NXT HTS from PerkinElmer. Data quality and analysis was performed using the GUItars program [] and sigmoidal curve fitting with Pipeline Pilot platform (Accelrys, v. 7.0.1). […]


Regulators of Autophagosome Formation in Drosophila Muscles

PLoS Genet
PMCID: 4334200
PMID: 25692684
DOI: 10.1371/journal.pgen.1005006

[…] al muscle area for each field. These values were then combined to give a measure of the total area of autophagosomes per muscle cell area per well. We used the MATLAB-based open-access software tool, GUItars, for subsequent calculation of SSMD scores of the RNAi screening data []. Strictly standardized mean difference (SSMD) of log-transformed data is the mean of log fold change divided by the sta […]


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GUItars institution(s)
Department of Chemical Biology and Therapeutics, St Jude Children’s Research Hospital, Memphis, TN, USA
GUItars funding source(s)
This work was supported by the American Lebanese Syrian Associated Charities (ALSAC), St. Jude Children’s Research Hospital, and National Cancer Institute grant P30CA027165.

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