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Unique identifier OMICS_30264
Alternative name GWAS heritability


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Publication for GWAS heritability

GWASH citations


Hidden heritability due to heterogeneity across seven populations

PMCID: 5642946
PMID: 29051922
DOI: 10.1038/s41562-017-0195-1

[…] recent meta-analysis of twin studies from 1958-2012 estimated, for instance, heritability for educational attainment as 52% (N=24,484 twin pairs) and 31% for reproductive traits (N=28,819 twin pairs).GWAS heritability estimates (h2GWAS) estimate the proportion of phenotypic variance accounted for by genetic variants known to be robustly associated with the phenotype of interest and produce the low […]


Classification of common human diseases derived from shared genetic and environmental determinants

Nat Genet
PMCID: 5577363
PMID: 28783162
DOI: 10.1038/ng.3931

[…] paring our heritability estimates with results from other independent studies, we first collected reference family heritability estimates for 65 out of the 149 traits we studied. We also collected 31 GWAS heritability estimates from literature. We reasoned that the two estimates for the same disease agreed with each other when their 95% confidence intervals overlapped. The comparisons are listed i […]


Genome wide association study identifies multiple risk loci for renal cell carcinoma

Nat Commun
PMCID: 5472706
PMID: 28598434
DOI: 10.1038/ncomms15724
call_split See protocol

[…] We estimated GWAS heritability, hl2, using the GCTA software and data from the NCI-1 and NCI-2 scans. Analyses assumed a disease prevalence of 1.66%, included only SNPs with MAF >0.05, removed subjects missing mor […]


The buffering capacity of stems: genetic architecture of nonstructural carbohydrates in cultivated Asian rice, Oryza sativa

New Phytol
PMCID: 5488208
PMID: 28556941
DOI: 10.1111/nph.14614

[…] the HDRA (McCouch et al., ), 222 689 had minor allele frequencies >0.05 in GLOBAL‐TRJ and were used in conjunction with six NIR‐predicted traits (starch, sucrose, and TNC at heading and maturity) for GWAS. Heritability estimates (Table ) for these traits in rice were lower than previously reported (Wang et al., ), likely due to glasshouse anomalies observed during this evaluation. These genome sca […]


Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome Wide Association Study Summary Level Data

PLoS Genet
PMCID: 5201242
PMID: 28036406
DOI: 10.1371/journal.pgen.1006493

[…] be highly enriched for heritability []. For example, recent heritability partitioning analysis has identified SNPs in conserved DNA regions, representing 2.6% of the genome, to be highly enriched for GWAS heritability for many diseases (explaining 35% heritability on average). Our theoretical calculations suggest that if only independent SNPs are analyzed, use of a subset of SNPs similarly enriche […]


Pedigree and SNP Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation

PLoS Genet
PMCID: 4737500
PMID: 26836320
DOI: 10.1371/journal.pgen.1005804

[…] loci through their association with recorded genetic markers and then aggregate the proportion of variance explained by statistically-significant variants [,], which is sometimes referred to as the “GWAS heritability” (hGWAS2). Each approach has its limitations and drawbacks. Pedigree studies require genealogical information from known relatives to deduce their expected genetic resemblance and hp […]


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GWASH institution(s)
Division of Biostatistics, University of California, San Diego, La Jolla, CA, USA; Institute of Biological Psychiatry, Mental Health Center St. Hans, Mental Health Services Copenhagen, Roskilde, Denmark
GWASH funding source(s)
Supported by NIH grant 1R01GM104400 and The Lundbeck Foundation Initiative for Integrative Psychiatric Research.

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