GWAsimulator statistics

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Associated diseases

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GWAsimulator specifications

Information


Unique identifier OMICS_04166
Name GWAsimulator
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages C++
Computer skills Advanced
Stability Stable
Maintained Yes

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Publication for GWAsimulator

GWAsimulator in publications

 (5)
PMCID: 5324069
PMID: 28233873
DOI: 10.1038/srep43381

[…] probe the number of false positive snps included in the prediction model, we injected phoney snps into the rectal bleeding modeling process. to do this, we generated 60,000 synthetic snps using the gwasimulator (http://biostat.mc.vanderbilt.edu/wiki/main/gwasimulator) relying on hapmap ceu data. with a p-value cutoff of 0.001, 74 snps remained. we combined these snps with 749 snps […]

PMCID: 4506584
PMID: 26187382
DOI: 10.1186/s12863-015-0225-9

[…] genotype data of the individuals in the general population based on the observed haplotype distributions in 180 kb and 174 kb regions of chromosomes 18 and 21 from the hapmap ceu samples using gwasimulator [], respectively. thus, the simulated individuals have genotypes in the regions of chromosomes 18 and 21 with similar ld structure to that of the hapmap ceu samples. we chose a pair […]

PMCID: 3322139
PMID: 22496761
DOI: 10.1371/journal.pone.0033716

[…] analyzed the simulated gwas data sets with the wga, the psa, and the wei. for the wei, we followed genovese et al. to specify r at 2, 5, or 10., we used a rapid whole-genome simulation program, the gwasimulator (http://biostat.mc.vanderbilt.edu/wiki/main/gwasimulator), to generate gwas data sets. the gwasimulator implements a rapid moving-window algorithm to simulate whole genome […]

PMCID: 3089490
PMID: 21317188
DOI: 10.1093/nar/gkr064

[…] entries and those that deviate from hardy–weinberg equilibrium with p-values below 5 × 10−7 (). see supplementary table s6 for more details and the number of subjects and snps in each dataset., the gwasimulator program () produces case and control genome-wide snp genotypes under a logistic regression disease model. it takes as input a control file that specifies various parameters […]

PMCID: 2873799
PMID: 20346093
DOI: 10.1186/gm142

[…] be simulated directly and only the required number of cases and controls needs to be simulated. this second approach has been used by many simulation programs, such as hapsample [], hapgen [] and gwasimulator []. as a compromise between these two approaches, a rejection-sampling algorithm can be used to simulate samples without simulating a large population (for example, genomesimla []). […]


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GWAsimulator institution(s)
Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA

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