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HADb specifications


Unique identifier OMICS_03308
Name HADb
Alternative name Human Autophagy Database
Restrictions to use None
Maintained Yes


  • Primates
    • Homo sapiens


  • person_outline Tony Kaoma

Publication for Human Autophagy Database

HADb citations


An autophagy related gene expression signature for survival prediction in multiple cohorts of hepatocellular carcinoma patients

PMCID: 5915122
PMID: 29707114
DOI: 10.18632/oncotarget.24089

[…] We obtained autophagy-related genes via database HADb. RNA-seq data of autophagy-related genes from each individual and their clinical information was download from the available TCGA database, which containing 374 HCC and 50 adjacent non-tumor tiss […]


Role of long chain acyl CoAs in the regulation of mycolic acid biosynthesis in mycobacteria

Open Biol
PMCID: 5541348
PMID: 28724694
DOI: 10.1098/rsob.170087

[…] random primers. The second-strand cDNA generated was used in qRT-PCR with green fluorochrome as the indicator dye (qPCR master mix, Biodynamics). The expression of mabR, fabD, acpM, kasA, kasB, inhA, hadB, fabH, fas, acpS, fasR was quantified after normalization of RNA levels to the expression of the sigA gene. All the primers were designed using Primer3 Plus software and their sequences are repor […]


Small ncRNA Expression Profiling of Blood from Hemophilia A Patients Identifies miR 1246 as a Potential Regulator of Factor 8 Gene

PLoS One
PMCID: 4503767
PMID: 26176629
DOI: 10.1371/journal.pone.0132433

[…] as clearly established that this genetic disease is caused by decreased FVIII activity []. Nonetheless, given the large diversity of individual mutations (well over a thousand) in the F8 gene (http://hadb.org.uk/), it is not clear that every HA case is caused by a functionally defective FVIII protein per se. Many HA patients are identified as CRM negative, i.e. no FVIII antigen is detected in the […]


Molecular basis for the inhibition of β hydroxyacyl ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors

PMCID: 4491049
PMID: 26081470
DOI: 10.1007/s13238-015-0181-1
call_split See protocol

[…] re of MtbHadAB was determined by the single-wavelength anomalous diffraction (SAD) method, using the peak data from selenium derivative. All the four expected selenium sites, one in HadA and three in HadB, were located using SHELXD program (Schneider and Sheldrick, ; Sheldrick, ), and the initial phases were calculated using PHENIX (Echols et al., ). The model of MtbHadAB complex was auto-built an […]


Foxk proteins repress the initiation of starvation induced atrophy and autophagy programs

Nat Cell Biol
PMCID: 4250422
PMID: 25402684
DOI: 10.1038/ncb3062

[…] ation (H3K4me1, H3K4me3, H3K27ac, H3K27me3), c-Jun, and RNA PolII ChIP-seq data were previously published,. C2C12 MyoD1 ChIP-seq data are available from ENCODE. Autophagy gene databases used were the Human Autophagy Database (http://autophagy.lu) and the mouse Autophagy Database (http://www.tanpaku.org/autophagy). The list of atrophy genes was obtained from http://agoldberg.med.harvard.edu/muscled […]


Interleukin 18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice

PMCID: 3749341
PMID: 23670974
DOI: 10.2337/db12-1095
call_split See protocol

[…] dilution points (range, 1–0.01); a no-template control; a no-reverse-transcriptase control; and 7.5 ng (0.375 ng for 18S rRNA) of each sample cDNA. For 18S rRNA, SREEBP1c, fatty acid synthase (FAS), HADB, phosphoenolpyruvate carboxykinase (PEPCK), glucose-6 phosphate dehydrogenase, and carnitine palmitoyl transferase 1 (CPT1), the amplification mixtures were prepared with 2X Taqman Universal PCR […]

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HADb institution(s)
Laboratory of Experimental Hemato-Oncology, Luxembourg City, Luxembourg

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