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|Interface||Web user interface|
|Restrictions to use||None|
|Input data||Inputs consist of the disease model file (the various types of specifications are given above) with specific rs#’s for the disease SNPs, and a file listing SNPs to be ‘genotyped’.|
|Output data||Output consists of SNP genotypes, reflecting current typing technologies. In addition, the output contains the simulated haplotypes, which are useful in evaluating the success of haplotype reconstruction approaches.|
Publication for HAP-SAMPLE
High Order SNP Combinations Associated with Complex Diseases: Efficient Discovery, Statistical Power and Functional Interactions
[…] We first used Hap-Sample simulator (http://www.hapsample.org, accessed 2012 Feb 20) to simulate genotype data with the 3404 SNPs from a recent study on multiple myeloma as input, out of which 2172 SNPs are include […]
Validation of a Cost Efficient Multi Purpose SNP Panel for Disease Based Research
[…] HAP-SAMPLE , a data based resampling simulation tool, was used to simulate genetically realistic genotypes for SNPs in the three panels plus SNPs in a candidate gene under a null model (in this case, […]
A survey of genetic simulation software for population and epidemiological studies
[…] iploid chromosomes from phased HapMap data followed by a single round of artificial meiosis, governed by empirical recombination rates also estimated from HapMap. This idea has been put to use in the HAP-SAMPLE software, with an additional option to boost the baseline recombination rate (x100 recommended) to reduce long-range linkage disequilibrium. Durrant et al.  proposed an alternative idea […]
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