haplo.stats statistics

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Citations per year

Number of citations per year for the bioinformatics software tool haplo.stats

Tool usage distribution map

This map represents all the scientific publications referring to haplo.stats per scientific context
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haplo.stats specifications


Unique identifier OMICS_10169
Name haplo.stats
Software type Toolkit/Suite
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License GNU General Public License version 2.0
Computer skills Advanced
Version 1.7.9
Stability Stable
methods, stats, graphics, R.rsp, R(≥3.0.0), rms
Maintained Yes


No version available



  • person_outline Jason Sinnwell

Publications for haplo.stats

haplo.stats citations


Genome wide haplotype association analysis of primary biliary cholangitis risk in Japanese

Sci Rep
PMCID: 5958065
PMID: 29773854
DOI: 10.1038/s41598-018-26112-1

[…] We used the R “haplo.stats” package, commonly employed in secondary explorations of haplotypes in single-SNP GWAS,, as our benchmark haplotype association analysis method. This method is used to obtain maximum likel […]


HLA class II haplotypes and Autism Spectrum Disorders

Sci Rep
PMCID: 5955937
PMID: 29769579
DOI: 10.1038/s41598-018-25974-9

[…] edictive variables. By default, calculations assume that a two-tailed statistical test was used at a confidence level of 95%.All analyses were performed with R version 3.2.0 (2015-04-16). The package haplo.stats (version 1.7.1) was used for the haplotype study. […]


Genetic Polymorphism at CCL5 Is Associated With Protection in Chagas’ Heart Disease: Antagonistic Participation of CCR1+ and CCR5+ Cells in Chronic Chagasic Cardiomyopathy

Front Immunol
PMCID: 5904358
PMID: 29696014
DOI: 10.3389/fimmu.2018.00615

[…] Genetic analyses were performed in R environment version 3.3.3 with the following packages: coin, epiDisplay, gap, genetics, haplo.stats, and SNPassoc. Comparisons among demographic or clinical variables were performed either by the chi-square test or Kruskal–Wallis test when appropriate. The association of genotypic and mi […]


Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis

PLoS One
PMCID: 5764259
PMID: 29324865
DOI: 10.1371/journal.pone.0190601

[…] nce values for multiple testing were applied using the Benjamini-Hochberg correction method (false-discovery rate–FDR values) as multiple SNPs were analysed.Haplotype frequencies were estimated using haplo.stats package 16 []. The haplo.score function was used to directly ascertain differences in haplotype distributions across the groups of MS patients and healthy controls. A global test of associ […]


Association between glutamate transporter gene polymorphisms and obsessive compulsive disorder/trait empathy in a South Korean population

PLoS One
PMCID: 5755803
PMID: 29304071
DOI: 10.1371/journal.pone.0190593
call_split See protocol

[…] ium (LD)’ approach in the control sample using Haploview v4.0 []. Associations between haplotype distributions and OCD under additive model were examined using the ‘haplo.score’ function of R package haplo.stats [], while adjusting for age and sex.In order to analyze the relationship between SLC1A1 variants and certain aspects of empathy measured with IRI, we used all available IRI data that were […]


Genetic Variants of the Receptor for Advanced Glycation End products in Susceptibility to Type 2 Diabetes Mellitus in Primary Hypertensive Patients

Sci Rep
PMCID: 5722821
PMID: 29222432
DOI: 10.1038/s41598-017-17068-9
call_split See protocol

[…] association magnitude between the RAGE gene and T2DM risk in primary hypertensive patients. Moreover, the frequencies of haplotypes based on 4 significant variants were estimated by using the program Haplo.Stats, version 1.7.7 developed by Sinnwell and Schaid (http://www.mayo.edu/research/labs/statistical-genetics-genetic-epidemiology/software). The omnibus association of derived haplotypes as a w […]

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haplo.stats institution(s)
Mayo Clinic/Foundation, Chinahester, MN, USA

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