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Haplotype phase inference software tools | Population genetics data analysis

Haplotype phase inference software tools | Population genetics data analysis Two categories of computational methods exist for determining haplotypes: haplotype phasing and haplotype assembly. Given the genotypes of a sample of individuals from a population, haplotype phasing attempts to infer the haplotypes of the sample using haplotype sharing information within the sample. In the related problem of genotype imputation, a phased reference panel is used to infer missing markers and haplotype phase of the sample. Methods for haplotype phasing and imputation are based on computational and statistical inference techniques, but both use the fact that closely spaced markers tend to be in linkage disequilibrium and smaller haplotypes blocks are often shared in a population of seemingly unrelated individuals.
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